Pharmaceutical Raw Materials Duloxetine Hydrochloride CAS 136434 - 34 - 9

Product Name: Duloxetine hydrochloride

Product Details:

Product name	Duloxetine hydrochloride
Synonyms	S)-DULOXETINE HYDROCHLORIDE;L248686;DULOXETINE HCL;(S)-DULOXETINE HYDROCHLORIDE;LY-248686;DULOXETINE HCL;DULOXETINE HYDROCHLORIDE;N-methyl-gamma-(1-naphthalenyloxy)-2-thiophenepropanamine, hydrochloride;(RS)Duloxetine HCl;(+)-(S)-N-Methyl-g-(1-naphthyloxy)-2-thiophenepropylamine;(gS)-N-Methyl-g-(1-naphthalenyloxy)-2-thiophenepropanamine
CAS	136434-34-9
EINECS	200-659-6
MF	C18H20ClNOS
MW	333.88
Mol File	136434-34-9.mol
MP	118-122°C
Certification	ISO9001
Appearance	White Crystalline Solid
Storage Temp	-20°C Freezer
Usage	having antidepressant effect, while also having inhibitory effect on the central pain

Description:

Duloxetine Hydrochloride is the hydrochloride salt of duloxetine, a fluoxetine derivative belonging to the class of selective serotonin (5-HT) and norepinephrine (NE) reuptake inhibitors (SSNRIs) and exhibiting antidepressant activity. Duloxetine selectively prevents the reuptake of 5-HT and NE via transporter complexes on the pre-synaptic membrane, thereby increasing the level of these neurotransmitters within the synaptic cleft. As a result, this agent potentiates serotonergic and noradrenergic activities in the central nervous system, and alleviates depression and neuropathy sensations, such as pain and tingling. Furthermore, duloxetine does not show significant affinity for dopaminergic, adrenergic, cholinergic, histaminergic, opioid, glutamate, and gamma-aminobutyric acid (GABA) receptors.

Duloxetine hydrochloride is a new kind of selective dual inhibitor of 5 hydroxy trptamine (5-HT) and norepinephrine reuptake, and thus having antidepressant effect, while also having inhibitory effect on the central pain. Its pharmacological characteristic is being able to inhibit neuronal pre-synaptic membrane's reuptake on 5-hydroxy trptamine and norepinephrine but instead have a low inhibitory effect on the reuptake of dopamine. Duloxetine hydrochloride is indicated for depression and it is effective in treating both endogenous and non-endogenous depression as well as the feeling of pain associated with depression. It has a therapeutic dose of 60mg/d~120mg/d with a good security and fewer adverse reactions with common adverse reactions such as nausea, dry mouth, constipation, poor appetite, fatigue, sleepiness, and increased sweating. Another indication is the pain caused by diabetic neuropathy.

Application:

1. Labelled Duloxetine, which is used as an antidepressant. A dual serotonin and norepinephrine reuptake inhibitor (SNRI).
2. An antidepressant. A dual serotonin and norepinephrine reuptake inhibitor (SNRI). Used in treatment of stress urinary incontinence.
3. leucotriene antagonist, antiasthmatic
4. anti-depressant, analgesic for osteoarthiritis and musculoskeletal pain
5. solubility H2O: soluble5 mg/mL (clear solution, warmed)

Duloxetine HCL is used to treat depression and anxiety. In addition, duloxetine is used to help relieve nerve pain (peripheral neuropathy) in people with diabetes or ongoing pain due to medical conditions such as arthritis, chronic back pain, or fibromyalgia (a condition that causes widespread pain). Duloxetine may improve your mood, sleep, appetite, and energy level, and decrease nervousness. It can also decrease pain due to certain medical conditions. Duloxetine is known as a serotonin-norepinephrine reuptake inhibitor (SNRI). This medication works by helping to restore the balance of certain natural substances (serotonin and norepinephrine) in the brain.

COA:

Product name	Duloxetine HCL
CAS	136434-34-9	Outer Packing		1KG foil bag
Standard adopted	Enterprise Standard
Items of analysis	Specification		Results
Description	White or off- white crystalline powder		White crystalline powder
Loss on drying (%)	Not more than 0.5%		0.20%
Melting Point	160.0～165.0℃		162.7～163.3
Specific Rotation	+115.0～+125.0°		+117.8°
Heavy metals	≤0.001%		＜0.001%
Purity(HPLC)	Single impurity≤0.5%		0.20%
Assay by HPLC(A%)	Not less than 98.0%		99.50%
Conclusion	Qualified

99% Pharmaceutical Raw Materials Powder Duloxetine Hcl CAS 136434 - 34 - 9 for Anti-Depressant Drug 0

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