|Place of Origin:||CHINA|
|Certification:||GMP , ISO 9001:2008|
|Minimum Order Quantity:||10g|
|Packaging Details:||Stealth and discreet packaging|
|Delivery Time:||Usually within 7 work days|
|Payment Terms:||Bank Transfer - Bitcoin - Western Union - MoneyGram|
|Supply Ability:||1000 KG/Month|
|EINECS:||252-974-3||Appearance:||Off-White To Pale Yellow Solid|
pharmaceutical active ingredients,
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Product Name: Piroxicam
Synonyms: PIROXICAM;PIROXICAMUM;2H-1,2-Benzothiazine-3-carboxamide, 4-hydroxy-2-methyl-N-2
Melting point 198-200°C
storage temp. 2-8°C
pka 6.3 (2:1 dioxane-water)
Water Solubility Soluble in water, ethanol, chloroform, ethyl acetate.
Used in Particular Diseases Acute Gouty Arthritis:
Dosage and Frequency: 20 mg once daily or 10 mg twice daily
Chemical Properties Off-White to Pale Yellow Solid
Uses Non-steroidal anti-inflammatory with long half-life. Cyclooxygenase inhibitor.
Clinically useful NSAID
Definition ChEBI: A monocarboxylic acid amide resulting from the formal condensation
of the carboxy group of 4-hydroxy-2-methyl-2H-1,2-benzothiazine-3-carboxylic acid 1,1-
dioxide with the exocyclic nitrogen of 2-aminopyridine.
Biological Activity Anti-inflammatory; highly selective inhibitor of COX-1 (ratio of IC
50 values for COX-2/COX-1 ~ 600).
Piroxicam is a nonsteroidal anti-inflammatory drug (NSAID) that is effective in treating fever, pain, and inflammation in the body. Piroxicam is used for the treatment of inflammation and pain caused by rheumatoid arthritis or osteoarthritis.
Piroxicam may increase the blood levels of lithium (Eskalith, Lithobid) by reducing the excretion of lithium by the kidneys. Increased levels of lithium may lead to lithium toxicity.
Piroxicam may reduce the blood pressure lowering effects of blood pressure medications. This may occur because prostaglandins play a role in the regulation (reduction) of blood pressure.
Combining NSAIDs such as piroxicam with angiotensin receptor blockers (for example, valsartan [Diovan], losartan [Cozaar], irbesartan [Avapro]) or angiotensin converting enzyme ACE) inhibitors (for example, enalapril [Vasotec], captopril [Capoten]) in patients who are elderly, volume-depleted (including those on diuretic therapy), or with poor kidney function may result in reduced kidney function, including kidney failure. These effects usually are reversible.
When piroxicam is used in combination with (Rheumatrex, Trexall) or aminoglycoside antibiotics (for example, gentamicin) the blood levels of or aminoglycoside may increase, presumably because the elimination of or aminoglycosides from the body is reduced. This may lead to more - or aminoglycoside- related side effects.
Individuals taking oral blood thinners or anticoagulants, for example, warfarin, (Coumadin), should avoid piroxicam because piroxicam also thins the blood, and excessive blood thinning may lead to bleeding.
Alcohol consumption may increase the risk of developing stomach ulcers when taking piroxicam or other NSAIDs.
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