Place of Origin: | CHINA |
---|---|
Brand Name: | TINGYI |
Certification: | GMP , ISO 9001:2008 |
Model Number: | CAS: 65-28-1 |
Minimum Order Quantity: | 10g |
Price: | Contact Us |
Packaging Details: | Stealth and discreet packaging |
Delivery Time: | Usually within 7 work days |
Payment Terms: | Bank Transfer - Bitcoin - Western Union - MoneyGram |
Supply Ability: | 3000KG/Month |
Product Name: | Phentolamine Mesilate | Purity: | 99% |
---|---|---|---|
CAS: | 65-28-1 | MF: | C18H23N3O4S |
MW: | 377.46 | Appearance: | White Crystalline Powder |
High Light: | pharmaceutical anabolic steroids,pharmaceutical fine chemicals |
Product Details:
Product Name
|
Phentolamine mesilate |
CAS
|
65-28-1 |
Alias
|
VASOMAX;phentolaminemethanesulphonate; phentolamine methanesulfonate; Phentolamine methanesulfonate salt; phentolamine mesilate |
Molecular Formula
|
C18H23N3O4S |
Molecular Weight
|
377.46 |
EINECS
|
200-604-6 |
Melting point
|
180-182 ℃ |
Boiling point
|
551 ° C at 760 mmHg |
Flash Point
|
287 ° C |
Water-soluble
|
50 mg / mL |
Purity
|
99.7% |
Grade
|
Pharmaceutical Grade |
Appearance
|
White crystalline powder |
Grade
|
Pharmaceutical Grade |
Phentolamine mesylate (OraVerse), a nonselective a-adrenergic blocking drug, is the first therapeutic agent marketed for the reversal of soft-tissue anaesthesia and the associated functional deficits resulting from an intraoral submucosal injection of a local anaesthetic containing a vasoconstrictor. In clinical trials, phentolamine injected in doses of 0.2 to 0.8 mg (0.5 to 2 cartridges), as determined by patient age and volume of local anaesthetic administered, significantly hastened the return of normal soft-tissue sensation in adults and children 6 years of age and older. Median lip recovery times were reduced by 75 to 85 minutes. Functional deficits, such as drooling and difficulty in drinking, smiling, or talking--and subjects' perception of altered function or appearance--were consistently resolved by the time sensation to touch had returned to normal. Adverse effects of phentolamine injected in approved doses for reversal of local anaesthesia in patients ranging in age from 4 to 92 years were similar in incidence to those of sham injections, and no serious adverse events caused by such use were reported. The clinical use of phentolamine is viewed favorably by dentists who have administered the drug and by patients who have received it. Optimal use may require some modifications of the technique described in the package insert; cost of the agent may be influencing its widespread adoption into clinical practice. Phentolamine mesylate, in the form of OraVerse (Novalar Pharmaceuticals, San Diego, USA) represents a new therapeutic class of drugs in dentistry intended to reverse soft-tissue anaesthesia after nonsurgical dental procedures (e.g., restorative or deep scaling/root planing procedures). As shown in Figure 1, OraVerse is manufactured in 1.7 mL dental cartridges, each of which contains 0.4 mg active drug. This review describes the development of phentolamine as a dental drug, its pharmacologic characteristics, and how it may be used in clinical practice to improve patient care.
At the same time, phentolamine mesylate for injection is the clinical common alpha adrenergic receptor blockers, circulating in the bloodstream can adersely affect the effect of epinephrine and norepinephrine, lower the blood vessels and peripheral vascular resistance and more used in the diagnosis and treatment of pheochromocytoma caused by the onset of hypertension, left ventricular failure and prevent skin necrosis.
Phentolamine mesylate (phentolamine mesylate, PM) for - the adrenaline receptor blockers, the alpha 1 and 2 receptor alpha have effect, has developed a tablet, capsule and injection preparation. Phentolamine mesylate tablets for alpha receptor potential competitive blocker, by blocking the alpha l receptor of vascular smooth muscle, and likely alpha 2 receptor, resulting in a decline in peripheral resistance and blood vessels, can make the corpus cavernosum smooth muscle relaxation, let more blood to flow into the spongy tissues, and inhibition of spongy tissue blood flow and leads to an erection. Phentolamine oral bioavailability is low, its clinical oral preparations for the treatment of erectile dysfunction. Phentolamine mesylate for injection is the clinical common alpha adrenergic receptor blockers, circulating in the bloodstream can adersely affect the effect of epinephrine and norepinephrine, lower the blood vessels and peripheral vascular resistance and more used in the diagnosis and treatment of pheochromocytoma caused by the onset of hypertension, left ventricular failure and prevent skin necrosis. The drug is the "Chinese pharmacopoeia" 2005 edition contains varieties.
Prevention or control of hypertensive episodes in patients with pheochromocytoma (excluding OraVerse ); pharmacologic test for pheochromocytoma (not method of choice) (excluding OraVerse ); prevention and treatment of dermal necrosis and sloughing following IV administration or extravasation of norepinephrine (excluding OraVerse ); reversal of soft-tissue anesthesia (ie, anesthesia of lip and tongue) ( OraVerse only).
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Nootropic Raw Powders |
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No. |
Name |
Cas no. |
1 |
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2 |
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3 |
Adrafinils |
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5 |
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6 |
Piracetam |
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7 |
Idebenone |
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8 |
Carphedon |
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9 |
Pramiracetam |
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10 |
Rivastigmine |
CAS:123441-03-2 |
11 |
Oxiracetam |
CAS:62613-82-5 |
12 |
Aniracetam |
CAS:72432-10-1 |
13 |
Donepezil |
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14 |
Rivastigmine tartrate |
CAS:129101-54-8 |
15 |
Alpha GPC |
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16 |
CRL-40,941(Fladrafinil) |
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17 |
Fasoracetam |
CAS:110958-19-5 |
18 |
Galantamine |
CAS:1953-04-4 |
19 |
9-fluorenol |
CAS:1689-64-1 |
20 |
NSI-189 free base |
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21 |
NSI-189 phosphate |
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22 |
Phenibut |
CAS:1078-21-3 |
23 |
Picamilon |
CAS:62936-56-5 |
24 |
PRL-8-53 |
CAS:51352-87-5 |
25 |
Tianeptine sodium |
CAS:30123-17-2 |
26 |
Vinpocetine |
CAS:42971-09-5 |
27 |
Vincamine |
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28 |
Theacrine |
CAS:2309-49-1 |
29 |
Unifiram |
CAS: 272786-64-8 |
30 |
CDP Citicoline |
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31 |
Huperzine A |
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32 |
brivaracetam |
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33 |
Etiracetam |
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34 |
Raubasine |
CAS:483-04-5 |
35 |
Entacapone |
CAS:130929-57-6 |
Name |
Purity |
Methylamine |
40% water solution |
Methylamine hydrochloride |
NLT 99% |
Benzeneacetonitrile (benzyl cyanide) |
NLT 99% |
Propiophenone |
NLT 99.5% |
Hydrogen bromide |
48% water solution |
(-)-Dibenzoyl-L-tartaric acid monohydrate |
NLT 99% |
Potassium borohydride |
NLT 97% |
Sodium borohydride |
NLT 98% |
6-(5-Chloro-2-pyridyl)-6,7-dihydro-7-hydroxy-5H-pyrrolo[3,4-b]pyrazin-5-one (CAS No:43200-81-3) |
NLT 99% |
N-PHENYLPIPERIDIN-4-AMINE DIHYDROCHLORIDE (4-ANP) CAS 99918-43-1 |
NLT 99% |
Pramipexole Hydrochloride |
NLT 99% |
Albuterol sulfate |
NLT 99% |
Dextromethorphan hydrobromide DXM |
NLT 99% |
Dimethocaine |
NLT 99% |
Dermorphin |
10mg/vial |
Sunifiram DM-235 |
NLT 99% |
Adrafinil |
NLT 99% |
Armodafinil |
NLT 99% |
PHENIBUT |
NLT 99% |
Suvorexant (MK-4305) |
NLT 99% |
Hetlioz (tasimelteon) |
NLT 99% |
Amitriptyline hydrochloride |
NLT 99% |
Mirtazapine |
NLT 99% |
Trazodone hydrochloride |
NLT 99% |
Venlafaxine hydrochloride |
NLT 99% |
Bupropion hydrochloride |
NLT 99% |
Sertraline hydrochloride |
NLT 99% |
N-Methylparoxetine |
NLT 99% |
Paroxetine hydrochloride |
NLT 99% |
Fluoxetine hydrochloride |
NLT 99% |
Citalopram hydrobromide |
NLT 99% |
Vortioxetine hydrobromide |
NLT 99% |
Vortioxetine |
NLT 99% |
Tianeptine |
NLT 99% |
5-Hydroxytryptophan 5-HTP |
NLT 98% |
gamma-butyrolactone (GBL) |
NLT 99.5% |
5a-Hydroxy Laxogenin |
NLT 98% |
Testosterone Steroid |
|
|
No. |
CAS NO |
Name |
1 |
CAS:58-22-0 |
Testosterone base |
3 |
CAS:76-43-7 |
Fluoxymesterone Halotestin |
4 |
CAS:2446-23-3 |
4-Chlorodehydromethyltestosterone(Oral turinabol) |
5 |
CAS:1255-49-8 |
Testosterone Phenylpropionate |
6 |
CAS:57-85-2 |
Testosterone Propionate |
7 |
CAS:1045-69-8 |
Testosterone acetate |
8 |
CAS:315-37-7 |
Testosterone enanthate |
9 |
CAS:58-20-8 |
Testosterone Cypionate |
10 |
CAS:1424-00-6 |
Mesterolone (Proviron) |
11 |
CAS:5949-44-0 |
Testosterone Undecanoate |
12 |
CAS:15262-86-9 |
Testosterone isocaproate |
13 |
CAS:855-19-6 |
Turinabol(4-Chlorotestosterone/Clostebol Acetate) |
14 |
CAS: NO |
Testosterone Sustanon 250/100 |
15 |
CAS:5721-91-5 |
Testosterone decanoate |
16 |
CAS:58-18-4 |
Methyltestosterone (17-methyltestosterone) |
17 |
CAS:58-20-8 |
1-Test Cyp,Dihydroboldenone Cypionate |
Boldenone Steroid |
|
|
17 |
CAS:846-48-0 |
Boldenone |
18 |
CAS:13103-34-9 |
Boldenone Undecylenate (Equipoise) |
19 |
CAS:846-46-0 |
Boldenone Acetate |
20 |
CAS:13103-34-9 |
Boldenone Propionate |
21 |
CAS:106505-90-2 |
Boldenone Cypionate |
Trenbolone Steroid |
|
|
22 |
CAS:10161-33-8 |
Trenbolone base |
23 |
CAS:10161-34-9 |
Trenbolone acetate(Finaplix H/Revalor-H) |
24 |
CAS:472-61-546 |
Trenbolone enanthate(parabolan) |
25 |
CAS:23454-33-3 |
Trenbolone Hexahydrobenzyl Carbonate |
Nandrolone Steroid |
|
|
26 |
CAS:434-22-0 |
Nandrolone |
27 |
CAS:62-90-8 |
Nandrolone Phenypropionate (NPP)/durabolin |
28 |
CAS: 601-63-8 |
Nandrolone cypionate |
29 |
CAS:360-70-3 |
Nandrolone decanoate(DECA)/ Deca durabolin |
30 |
CAS: 862-89-5 |
Nandrolone Undecylate |
31 |
CAS: 7207-92-3 |
Nandrolone propionate |
Primobolan Steroid |
|
|
32 |
CAS:434-05-9 |
Methenolone Acetate(Primobolan) |
33 |
CAS:303-42-4 |
Methenolone enanthate (USAN) |
34 |
CAS: 153-00-4 |
Metenolone |
35 |
CAS:3381-88-2 |
Superdrol Powder/Methasterone (methyl-drostanolone) |
36 |
CAS:521-12-0 |
Drostanolone Propionate (Masteron) |
37 |
CAS:472-61-145 |
Drostanolone Enanthate(Masteron) |
Anabolic Steroids |
|
|
38 |
CAS:72-63-9 |
Methandrostenolone (Dianabol, methandienone) |
39 |
CAS:3704-09-4 |
Mibolerone |
40 |
CAS:965-93-5 |
Methyltrienolone (Metribolone) |
41 |
CAS:5197-58-0 |
Methylstenbolone |
42 |
CAS: 5630-53-5 |
Tibolone |
43 |
CAS:521-11-9 |
Mestanolone |
44 |
CAS:521-18-6 |
Stanolone (androstanolone) |
45 |
CAS:434-07-1 |
Oxymetholone (Anadrol) |
46 |
CAS:53-39-4 |
Oxandrolone(Anavar) |
47 |
CAS:10418-03-8 |
stanozolol(Winstrol) |
48 |
CAS:6157-87-5 |
Trestolone acetate |
49 |
CAS:853-23-6 |
Dehydroisoandrosterone 3-acetate |
50 |
CAS:53-43-0 |
Dehydroepiandrosterone (DHEA) |
51 |
CAS:481-29-8 |
Epiandrosterone |
52 |
CAS:566-19-8 |
7-Keto-dehydroepiandrosterone |
53 |
CAS:76822-24-7 |
1-DHEA |
Testosterone Acetate |
Trenbolone Acetate |
MGF |
Testosterone Cypionate |
Trenbolone Enanthate |
PEG MGF |
Testosterone Decanoate |
Boldenone Acetate |
CJC-1295 |
Testosterone Enanthate |
Boldenone undecylenate |
CJC-1295 DAC |
Testosterone Isocaproate |
Boldenone Cypionate |
PT-141 |
Testosterone Phenylpropionate |
Boldenone Propionate |
Melanotan-1 |
Testosterone Propionate |
Nandrolone Decanoate |
Melanotan-2 |
Testosterone Undecanoate |
Nandrolone phenylpropionate |
GHRP-2 |
Mesterone |
Nandrolone undecylate |
GHRP-6 |
Testosterone Sustanon 250 |
Nandrolone cypionate |
Ipamorelin |
Clostebol Acetate |
Nandrolone propionate |
Hexarelin |
Methylandrostanolone |
Methyltrienolone |
Sermorelin |
Methenolone Enanthate |
Drostanolone Propionate |
Oxytocin |
Methenolone Acetate |
Drostanolone Enanthate |
TB500 |
Anadrol |
Stanolone |
Fragment 176-191 |
Anavar |
Tadalafil |
Triptorelin |
Winstrol |
Vardenafil |
Tesamorelin |
Clomifene citrate |
Dianabol |
Gonadorelin |
Toremifene citrate |
Tamoxifen Citrate |
DSIP |
Finasteride |
hydrochloride |
Selank |
Benzocaine |
Liothyronine sodium T3 |
L-Carnitine |