99% Phentolamine Mesilate Pharmaceutical Raw Materials CAS 65-28-1 For Sex Enhancer

Basic Information
Place of Origin: CHINA
Brand Name: TINGYI
Certification: GMP , ISO 9001:2008
Model Number: CAS: 65-28-1
Minimum Order Quantity: 10g
Price: Contact Us
Packaging Details: Stealth and discreet packaging
Delivery Time: Usually within 7 work days
Payment Terms: Bank Transfer - Bitcoin - Western Union - MoneyGram
Supply Ability: 3000KG/Month
Product Name: Phentolamine Mesilate Purity: 99%
CAS: 65-28-1 MF: C18H23N3O4S
MW: 377.46 Appearance: White Crystalline Powder
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99% Pharmaceutical Raw Materials Adrenergic Blocking Medication Phentolamine Mesylate CAS 65-28-1 For Sex Enhancer

Product Name: Phentolamine mesilate

 

Product Details:

 

 

Product Name

 

Phentolamine mesilate

 

CAS

 

65-28-1

 

Alias

 

VASOMAX;phentolaminemethanesulphonate; phentolamine methanesulfonate; Phentolamine methanesulfonate salt; phentolamine mesilate

 

Molecular Formula

 

 

C18H23N3O4S

 

Molecular Weight

 

 

377.46

 

EINECS

 

200-604-6

 

Melting point

 

180-182 ℃

 

Boiling point

 

551 ° C at 760 mmHg

 

Flash Point

 

287 ° C

 

Water-soluble

 

50 mg / mL

 

Purity

 

99.7%

 

Grade

 

Pharmaceutical Grade

 

Appearance

 

White crystalline powder

 

Grade

 

Pharmaceutical Grade

 

 

Descriptions:

 

Phentolamine mesylate (OraVerse), a nonselective a-adrenergic blocking drug, is the first therapeutic agent marketed for the reversal of soft-tissue anaesthesia and the associated functional deficits resulting from an intraoral submucosal injection of a local anaesthetic containing a vasoconstrictor. In clinical trials, phentolamine injected in doses of 0.2 to 0.8 mg (0.5 to 2 cartridges), as determined by patient age and volume of local anaesthetic administered, significantly hastened the return of normal soft-tissue sensation in adults and children 6 years of age and older. Median lip recovery times were reduced by 75 to 85 minutes. Functional deficits, such as drooling and difficulty in drinking, smiling, or talking--and subjects' perception of altered function or appearance--were consistently resolved by the time sensation to touch had returned to normal. Adverse effects of phentolamine injected in approved doses for reversal of local anaesthesia in patients ranging in age from 4 to 92 years were similar in incidence to those of sham injections, and no serious adverse events caused by such use were reported. The clinical use of phentolamine is viewed favorably by dentists who have administered the drug and by patients who have received it. Optimal use may require some modifications of the technique described in the package insert; cost of the agent may be influencing its widespread adoption into clinical practice. Phentolamine mesylate, in the form of OraVerse (Novalar Pharmaceuticals, San Diego, USA) represents a new therapeutic class of drugs in dentistry intended to reverse soft-tissue anaesthesia after nonsurgical dental procedures (e.g., restorative or deep scaling/root planing procedures). As shown in Figure 1, OraVerse is manufactured in 1.7 mL dental cartridges, each of which contains 0.4 mg active drug. This review describes the development of phentolamine as a dental drug, its pharmacologic characteristics, and how it may be used in clinical practice to improve patient care.

 

At the same time, phentolamine mesylate for injection is the clinical common alpha adrenergic receptor blockers, circulating in the bloodstream can adersely affect the effect of epinephrine and norepinephrine, lower the blood vessels and peripheral vascular resistance and more used in the diagnosis and treatment of pheochromocytoma caused by the onset of hypertension, left ventricular failure and prevent skin necrosis.
Phentolamine mesylate (phentolamine mesylate, PM) for - the adrenaline receptor blockers, the alpha 1 and 2 receptor alpha have effect, has developed a tablet, capsule and injection preparation. Phentolamine mesylate tablets for alpha receptor potential competitive blocker, by blocking the alpha l receptor of vascular smooth muscle, and likely alpha 2 receptor, resulting in a decline in peripheral resistance and blood vessels, can make the corpus cavernosum smooth muscle relaxation, let more blood to flow into the spongy tissues, and inhibition of spongy tissue blood flow and leads to an erection. Phentolamine oral bioavailability is low, its clinical oral preparations for the treatment of erectile dysfunction. Phentolamine mesylate for injection is the clinical common alpha adrenergic receptor blockers, circulating in the bloodstream can adersely affect the effect of epinephrine and norepinephrine, lower the blood vessels and peripheral vascular resistance and more used in the diagnosis and treatment of pheochromocytoma caused by the onset of hypertension, left ventricular failure and prevent skin necrosis. The drug is the "Chinese pharmacopoeia" 2005 edition contains varieties.

 

 

 

Applications:

 

Prevention or control of hypertensive episodes in patients with pheochromocytoma (excluding OraVerse ); pharmacologic test for pheochromocytoma (not method of choice) (excluding OraVerse ); prevention and treatment of dermal necrosis and sloughing following IV administration or extravasation of norepinephrine (excluding OraVerse ); reversal of soft-tissue anesthesia (ie, anesthesia of lip and tongue) ( OraVerse only).

 

 

 

 

 

99% Phentolamine Mesilate Pharmaceutical Raw Materials CAS 65-28-1 For Sex Enhancer 0

 

 

Our Company Advantages:

 

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1) Standard: U.S Standard
2) All Purity≥99.8%
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1) Parcel can be sent out within 8 hours after payment. Tracking number available
2) Secure and discreet shipment. Various transportation methods for your choice.
3) Customs pass rate ≥99.8%
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