| Place of Origin: | CHINA |
|---|---|
| Brand Name: | TINGYI |
| Certification: | GMP , ISO 9001:2008 |
| Model Number: | CAS: 86347-14-0 |
| Minimum Order Quantity: | 10g |
| Price: | Contact Us |
| Packaging Details: | Stealth and discreet packaging |
| Delivery Time: | Usually within 7 work days |
| Payment Terms: | Bank Transfer - Bitcoin - Western Union - MoneyGram |
| Supply Ability: | 3000KG/Month |
| Product Name: | Medetomidine | Purity: | 99% |
|---|---|---|---|
| CAS: | 86347-14-0 | MF: | C18H23N3O4S |
| MW: | 377.46 | Appearance: | White Crystalline Powder |
| High Light: | pharmaceutical anabolic steroids,pharmaceutical fine chemicals |
||
|
Product name
|
Medetomidine |
|
Alias |
medetomidine;Medetomidine [inn:ban];(rac)-4-[1-(2,3-dimethylphenyl)ethyl]-3H-imidazole;4-(1-(2,3-Dimethylphenyl)ethyl)-1H-imidazole;Medetomidina [spanish];Medetomidinum;Medetomidine; DoMtor;Medetomidina
|
|
Original
|
China |
|
CAS
|
86347-14-0 |
|
Molecular formula
|
C13H16N2 |
|
MW
|
200.28000 |
|
Purity
|
99% |
|
Density
|
1.053g/cm3 |
|
MP
|
151.5 - 152.5ºC |
|
BP
|
381.9ºC at 760 mmHg |
|
Flash point
|
191.3ºC |
|
Refractive index
|
1.569 |
|
Appearance
|
White crystals |
Medetomidine is a relatively new sedative analgesic.Medetomidine is a potent and highly specific α2-adrenoreceptor agonist that has been used extensively in Europe and is registered in 34 countries world-wide. It is licensed for IM and IV use only in dogs in Canada and the United States, but in other countries, such as the United Kingdom and Finland, it is approved for use in both dogs and cats. Medetomidine is a lipophillic compound that is rapidly and completely absorbed after IM injection.
The beneficial effects of medetomidine are the same as those of other α22-agonists and include reliable sedation, analgesia, muscle relaxation, and anxiolysis, as well as a decrease in the anesthetic requirements of injectable and inhalant agents (anesthetic sparing). It is not a controlled substance and, therefore, does not require extensive record keeping.
Medetomidine is a synthetic drug used as both a surgical anesthetic and analgesic. It is often used as the hydrochloride salt, medetomidine hydrochloride, a crystalline white solid. It is an α2 adrenergic agonist that can be administered as an intravenous drug solution with sterile water.
The drug has been developed by Orion Pharma. It is currently approved for dogs in the United States, and distributed in the United States by Pfizer Animal Health and by Novartis Animal Health in Canada under the product name Domitor. Other alpha-two agonists used in veterinary medicine include xylazine and detomidine, but their use is less common in small animal surgery.
(1) In veterinary medicine
It is often used in combinations with opioids (butorphanol, buprenorphine etc.) as premedication (before a general anesthetic) in healthy cats and dogs. It can be given by intramuscular injection (IM), subcutaneous injection (SC) or intravenous injection (IV). When delivered intravenously, a significantly decreased dose is used. Some authors suggest a sublingual route is also effective.
It is not recommended for diabetics, it is contraindicated in patients with cardiac disease. Due to its potent sedative effects it is commonly used in more aggressive animals, where a drug combination with a lesser effect (such as acepromazine plus an opioid, or an opioid plus a benzodiazepine) would not allow the administration of the inductive agent without risk to the veterinarian. As such the use of alpha-two agonists is only recommended in healthy animals.
It is sometimes used in combination with butorphanol and ketamine (given IM) to produce general anasthesia for short periods in healthy but fractious felines that will not allow an intravenous induction agent to be given. It provides a good degree of muscle relaxation, an important factor in ketamine based anethesia protocols.
Medetomidine has also been used in combination with morphine (or methadone), lidocaine and ketamine in constant rate infusion analgesia in canines. It is often used in so called microdoses for this analgesic effect.
It is thought that this family of drugs has a degree of analgesic action, though this is, in comparison to the sedative effect, minor.
(2) In marine paint
Medetomidine can be used as an antifouling substance in marine paint. It is mainly effective against barnacles, but has also shown effect on other hard fouling like tube worms. When the barnacle cyprid larva encounters a surface containing medetomidine the molecule interacts with the octopamine receptor in the larva. This makes the larva legs start kicking and it cannot settle to the painted surface. When the larva swims away from the surface, the effect disappears (reversible effect). The larva regain its function and can settle somewhere else.
The beneficial effects of medetomidine are the same as those of other α22-agonists and include reliable sedation, analgesia, muscle relaxation, and anxiolysis, as well as a decrease in the anesthetic requirements of injectable and inhalant agents (anesthetic sparing). It is not a controlled substance and, therefore, does not require extensive record keeping. These qualities make medetomidine a viable option in small animal anesthesia. Unfortunately, the negative cardiovascular effects of earlier α2-agonists (xylazine), including bradycardia and associated arrhythmias, hypertension or hypotension, and reduced cardiac output, are still observed with medetomidine and cause concern among clinicians with respect to their use as premedication or sedative agents.
|
TEST
|
SPECIFICATIONS |
RESULTS |
|
Appearance
|
White or off-white crystalline powder |
White crystalline powder |
|
Solubility
|
Conforms |
Conforms |
|
-1
|
Positive |
Positive |
|
-2
|
Conforms |
Conforms |
|
-3
|
Positive |
Positive |
|
Specific rotation
|
+51°~+54° |
+53.8° |
|
PH
|
3.5-4.5 |
4.3 |
|
Clarity and Color of Solution
|
Conforms |
Conforms |
|
Related Substance
|
≤1.0% |
0.20% |
|
The max unknown substance
|
≤0.1% |
<0.1% |
|
Levmedetomidine HCL
|
≤1.0% |
0.03% |
|
Loss on drying
|
≤1.0% |
0.19% |
|
Residue on Ignition
|
≤0.1% |
0.07% |
|
Heavy Metal
|
≤10ppm |
Conforms |
|
Assay
|
≥98.5%(anhydrous, containing Medetomidine Hydrochloride) |
99.60% |
|
Conclusion
|
The results can conforms with the enterprise standard |
|
1, High quality with competitive price:
1) Standard: U.S Standard
2) All Purity≥99.8%
3) We are manufacturer and can provide high quality products with factory price.
2, Fast and safe delivery
1) Parcel can be sent out within 8 hours after payment. Tracking number available
2) Secure and discreet shipment. Various transportation methods for your choice.
3) Customs pass rate ≥99.8%
4)We provide re-ship policy.
5) We have warehouse in Australia, Canada and England, we have large amounts of stock in the warehouse, can ship to you directly from our foreign warehouse!
3, We have clients throughout the world.
1) Professional service and rich experience make customers feel at ease, adequate stock and fast delivery meet their desire.
2) Meeting customers's requirement is our responsibility.
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Name |
Purity |
|
Methylamine |
40% water solution |
|
Methylamine hydrochloride |
NLT 99% |
|
Benzeneacetonitrile (benzyl cyanide) |
NLT 99% |
|
Propiophenone |
NLT 99.5% |
|
Hydrogen bromide |
48% water solution |
|
(-)-Dibenzoyl-L-tartaric acid monohydrate |
NLT 99% |
|
Potassium borohydride |
NLT 97% |
|
Sodium borohydride |
NLT 98% |
|
6-(5-Chloro-2-pyridyl)-6,7-dihydro-7-hydroxy-5H-pyrrolo[3,4-b]pyrazin-5-one (CAS No:43200-81-3) |
NLT 99% |
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N-PHENYLPIPERIDIN-4-AMINE DIHYDROCHLORIDE (4-ANP) CAS 99918-43-1 |
NLT 99% |
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Pramipexole Hydrochloride |
NLT 99% |
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Albuterol sulfate |
NLT 99% |
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Dextromethorphan hydrobromide DXM |
NLT 99% |
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Dimethocaine |
NLT 99% |
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Dermorphin |
10mg/vial |
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Sunifiram DM-235 |
NLT 99% |
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Adrafinil |
NLT 99% |
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Armodafinil |
NLT 99% |
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PHENIBUT |
NLT 99% |
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Suvorexant (MK-4305) |
NLT 99% |
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Hetlioz (tasimelteon) |
NLT 99% |
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Amitriptyline hydrochloride |
NLT 99% |
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Mirtazapine |
NLT 99% |
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Trazodone hydrochloride |
NLT 99% |
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Venlafaxine hydrochloride |
NLT 99% |
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Bupropion hydrochloride |
NLT 99% |
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Sertraline hydrochloride |
NLT 99% |
|
N-Methylparoxetine |
NLT 99% |
|
Paroxetine hydrochloride |
NLT 99% |
|
Fluoxetine hydrochloride |
NLT 99% |
|
Citalopram hydrobromide |
NLT 99% |
|
Vortioxetine hydrobromide |
NLT 99% |
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Vortioxetine |
NLT 99% |
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Tianeptine |
NLT 99% |
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5-Hydroxytryptophan 5-HTP |
NLT 98% |
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gamma-butyrolactone (GBL) |
NLT 99.5% |
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CAS NO |
Name |
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1 |
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Testosterone base |
|
3 |
CAS:76-43-7 |
Fluoxymesterone Halotestin |
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4 |
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5 |
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6 |
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Testosterone Propionate |
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8 |
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9 |
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Testosterone Cypionate |
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10 |
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11 |
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12 |
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Testosterone isocaproate |
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13 |
CAS:855-19-6 |
Turinabol(4-Chlorotestosterone/Clostebol Acetate) |
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14 |
CAS: NO |
Testosterone Sustanon 250/100 |
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15 |
CAS:5721-91-5 |
Testosterone decanoate |
|
16 |
CAS:58-18-4 |
Methyltestosterone (17-methyltestosterone) |
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17 |
CAS:58-20-8 |
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Boldenone Steroid |
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17 |
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Boldenone |
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18 |
CAS:13103-34-9 |
Boldenone Undecylenate (Equipoise) |
|
19 |
CAS:846-46-0 |
Boldenone Acetate |
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20 |
CAS:13103-34-9 |
Boldenone Propionate |
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21 |
CAS:106505-90-2 |
Boldenone Cypionate |
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Trenbolone Steroid |
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22 |
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Trenbolone base |
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23 |
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24 |
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25 |
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26 |
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27 |
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Nandrolone Phenypropionate (NPP)/durabolin |
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28 |
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29 |
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31 |
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32 |
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33 |
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34 |
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35 |
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37 |
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Anabolic Steroids |
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Methandrostenolone (Dianabol, methandienone) |
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39 |
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40 |
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Methyltrienolone (Metribolone) |
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41 |
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42 |
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Tibolone |
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43 |
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Mestanolone |
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44 |
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Stanolone (androstanolone) |
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Oxymetholone (Anadrol) |
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Oxandrolone(Anavar) |
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Trestolone acetate |
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49 |
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Dehydroisoandrosterone 3-acetate |
|
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Dehydroepiandrosterone (DHEA) |
|
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Epiandrosterone |
|
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7-Keto-dehydroepiandrosterone |
|
53 |
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