99% Purity White Crystal Powder Raw Pharmaceutical Materials  Quinine CAS: 130-95-0 For Antimalarial Drugs 

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Description

Quinine, also known as Jinji Nashuang Cream and Cinchona Alkali, is the main alkaloid in the bark of the Rubiaceae plant and its genus. The cinchona bark contains more than 20 kinds of alkaloids. Also involved in malaria are quinidine, cinchonine and cinchonidine. The whole alkaloids of the cinchona bark are used as antimalarials and antipyretics, and are called cinchona or total quinine. Quinine is chemically a quinoline and is an isomer with quinidine. White amorphous powder or crystal, odorless, very bitter taste. The melting point is 172.8 ° C, with left-handed optical, [α] D20-168 ° (ethanol). Soluble in ethanol, chloroform, benzene, ether, slightly soluble in water. The dilute sulfuric acid solution has blue fluorescence, and bromine water and excess ammonia water are added dropwise, which is emerald green. The cinchona bark powder is treated with lime and sodium hydroxide, kerosene is extracted, and dilute sulfuric acid is neutralized, and the precipitated quinine sulfate is reacted with ammonia. It is also possible to synthesize m-hydroxybenzaldehyde from α-aminoacetaldehyde as a raw material. It is used to treat and prevent various malaria, and its medicinal is its sulfate or hydrochloride.

Quinine is a substance that was first obtained by processing the bark of the cinchona tree, a South American native plant that has been used as a fever reducer by Native Americans for centuries. This substance has been used historically to treat malaria, along with some other medical conditions, and although a number of antimalarial drugs are on the market today, it is still used in some regions. It is also used commercially as an additive to tonic water, a soft drink that is used as a mixer for other drinks in addition to being consumed straight.

Application

An alkaloid derived from the bark of the cinchona tree.It is used as an antimalarial drug, and is the active ingredient in extracts of the cinchona that have been used for that purpose since before 1633.Quinine is also a mild antipyretic and analgesic and has been used in common cold preparations for that purpose.

Quinine was used commonly and as a bitter and flavoring agent, and is still useful for the treatment of babesiosis. emeraldgo(at)hotmail.com.Quinine is also useful in some muscular disorders, especially nocturnal leg cramps and myotonia congenita, because of its direct effects on muscle membrane and sodium channels. The mechanisms of its antimalarial effects are not well understood.

Quinine is one of the oldest antimalarial drugs. As early as the 15th century, the cinchona bark containing quinine has become a special drug widely used in the treatment of malaria. Its antimalarial effect is similar to that of chloroquine, which interferes with DNA synthesis. effect. It can inhibit the red blood cell phase of various malaria parasites and control the onset of malaria symptoms. There is also a certain killing effect on gametophytes of vivax malaria and three-day malaria. However, it has no effect on the extracellular phase of red blood cells. Its main advantage is that it is not easy to produce drug resistance. It may be that quinine and Plasmodium have different DNA binding methods than chloroquine, so there is no cross-resistance and it can be used for anti-chloroquine strains (especially Plasmodium falciparum) infection. In addition, quinine also has the effect of stimulating the uterus, inhibiting the heart muscle and relieving heat and relieving pain. In addition to medicinal use, it can be used as a detection agent for metal ions such as ruthenium and platinum in analytical chemistry, and as a precipitation agent for racemic organic acids.

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