Anti Cancers Powder Active Pharmaceutical Ingredient Temozolomide CAS 85622-93-1

Basic Information
Place of Origin: CHINA
Brand Name: TINGYI
Certification: GMP , ISO 9001:2008
Model Number: CAS: 85622-93-1
Minimum Order Quantity: 10g
Price: Contact Us
Packaging Details: Stealth and discreet packaging
Delivery Time: Usually within 7 work days
Payment Terms: Bank Transfer - Bitcoin - Western Union - MoneyGram
Supply Ability: 5000kg/Month
Product Name: Temozolomide CAS: 85622-93-1
MF: C6H6N6O2 MW: 194.15084
Purity: 99% Appearance: White To Light Brown Powder
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High Quality Temozolomide CAS 85622-93-1 for Anti-Cancers

 

Product Name: Temozolomide

 

Product Details:

 

Product Name: Temozolomide
Synonym: 4-methyl-5-oxo-2,3,4,6,8-pentazabicyclo[4.3.0]nona-2,7,9-triene-9-carboxamide;TEMOZOLOMIDE;methazolastone;nsc362856;temodar;Temozolamide;Temozolimide;3,4-Dihydro-3-methyl-4-oxoimidazo[5,1-d]-1,2,3,5-tetrazin-4(3H)-one, Methazolastone, M&B 39831, Temodal, Temodar,
CAS: 85622-93-1
MF: C6H6N6O2
MW: 194.15084
EINECS: 630-358-9
Melting Point: 212°C dec.
Storage: 2-8°C
Solubility: DMSO: soluble10mg/mL, clear
Appearance: white to light brown powder
Merck: 14,9139
Chemical Properties:
Crystallized from dichloromethane, melting point 212 ° C (decomposition). UV maximum absorption (95% ethanol): 327 nm.
Use: Antineoplastic agents. It can spontaneously and rapidly degrade in vivo to produce the active metabolite MTIC, which produces an anti-tumor effect.

 

 

 

Anti Cancers Powder Active Pharmaceutical Ingredient Temozolomide CAS 85622-93-1 0

Name: Temozolomide 85622-93-1

Appearance: white powder

Cas No: 85622-93-1

EINECS: 630-358-9

Formula: C6H6N6O2

Molecular Weight:194.15

Melting Point: 212.0 °C

Boiling Point: 526.6 °C

Flash Point: 272.3 °C

Usage: antineoplastics

Testing Items

Standards: Enterprise

Appearance

A white to light pinkish white crystalline powder

Identification

should conform

Loss on drying

NMT0.5%

Residual on ignition

NMT0.1%

Heavy metals

NMT10ppm

Related substances

AICA: NMT0.15%

DIAZO:NMT0.15%

other single impurity:NMT0.1%

Total Unknown Impurities:NMT0.2%

Total Impurities:NMT0.5%

Microbial limits

Bacterial Counts:NMT1000/g

Fungi and yeasts:NMT100/g

E.Coli: Should be negative

Assay(by HPLC)

98.0% ~102.0%

 

 

 

Description:

 

Temozolomide is the first orally effective imidazotetrazine antitumor drug. It belongs to the second generation of alkylating agent with antitumor activity. It does not require intrahepatic metabolic activation after oral administration. It is characterized by easy permeability through the blood-brain barrier and tolerance. It has good compatibility with other drugs and has synergistic effect with radiotherapy. It is suitable for malignant gliomas that have recurred after conventional treatment, such as glioblastoma multiforme or degenerative astrocytoma. It is also a treatment for metastasis. The first line of melanoma. Temozolomide was synthesized by the British Cancer Research Group and later transferred to the US Schering-Plough Company for development. This drug is different from the existing anti-tumor drugs. It has a novel chemical structure and is an imidazotetrazine derivative. Temozolomide does not directly function. At physiological pH, it is rapidly converted to the active compound MTIC via a non-enzymatic pathway [5- (3-methyltriazene-1-)imidazole-4-amide]. It is believed that the cytotoxicity of MTIC is mainly due to its DNA alkylation (methylation), which occurs mainly at the O6 and N7 positions of guanine. Temozolomide has been shown to be effective in some of the most common gliomas through basic and clinical studies. It was approved for marketing in the European Union and the United States in 1999. The US approved indications are glioblastoma multiforme and degenerative star cells. Second-line treatment of gliomas such as tumors, and the approved indications in the EU countries are glioblastomas that still develop or relapse after conventional treatment. The effect of temozolomide on pleomorphic glioblastoma has gained more recognition in Europe.


The drug is completely absorbed orally, and its bioavailability is nearly 100%. It exhibits broad-spectrum activity in a murine tumor model and can penetrate the human blood-brain barrier. The cytotoxic effect of temozolomide stems from its strong methylation of DNA bases. Under alkaline conditions, temozolomide can be rapidly cleaved to form active methyldiazo ions. Because the brain tumor has higher alkalinity than the surrounding tissue, the activation of the drug can be concentrated in the tumor site, the anti-tumor effect is strong and selective, the side effect spectrum is also improved, the bone marrow toxicity is small, and the patient is tolerant. Sexual improvement.

 

 

 

Application:

 

The effect of temozolomide in the treatment of recurrent glioblastoma multiforme has been confirmed to be safe and effective in clinical trials. A phase II randomized controlled trial showed that 225 patients with first-stage relapsed glioblastoma were treated with temozolomide or procarbazine (administered for 125 days every 56 days, orally 125-150 mg/m2 daily). At 6 months, there was no progression in the temozolomide group. Survival and overall survival were 21% and 60%, respectively, significantly higher than 8% and 44% of the procarbazine group. The mean progression-free survival and overall survival of patients with temozolomide were 2.9 and 7.3 months, respectively, and were significantly higher than the 1.9 and 5.8 months of the procarbazine group. The trial also performed a health-related quality of life assessment at the 3rd and 6th months after the start of treatment. The results also confirmed that more patients in the temozolomide group had improved quality of life or remained stable. The main adverse effects of temozolomide were transient and non-accumulative myelosuppression, which was predictable and easy to handle, with an incidence of 24% in the trial. Temozolomide also causes mild to moderate nausea and vomiting in patients, but can be prevented by conventional antiemetic therapy. The efficacy and adverse drug reactivity of temozolomide in recurrent glioblastoma multiforme were significantly better than the existing standard drug procarbazine.

Temozolomide is effective in the treatment of newly diagnosed glioblastoma multiforme. A small phase II trial showed that after treatment with temozolomide (200 mg/m2) in 33 of these patients, 17 patients achieved complete or partial remission, and another 4 patients were stable. The average time to recover from the condition of the 17 patients to 7 months was 7 months, while those who did not respond to treatment were 2 months. Their average survival time was 12 months and 6 months, respectively. However, the effect of temozolomide on newly diagnosed degenerative astrocytoma is still unclear. Temozolomide has a significant effect on gliomas, especially on the most common pleomorphic glioblastoma, both in tumor response rate and in patient survival and tolerability. More importantly, the quality of life of patients is significantly better than the existing standard drug procarbazine, making the treatment of such tumors a welcome step. The effect of temozolomide on the first-line treatment of progressive metastatic melanoma has also been affirmed in clinical trials, and applications have been filed in Europe, the United States and other countries. A recently published phase III randomized controlled trial showed that 305 patients in the temozolomide group were treated with temozolomide (200 mg/m2) and dacarbazine (administered for 5 days every day for 25 days, 250 mg/m2 per day). Overall survival and treatment response rates were 7.9 months and 13.5%, respectively, which was better than 5.7 months and 12.1% in the dacarbazine group. Patients in the temozolomide group were better tolerated than the dacarbazine group, and the quality of life assessment with reduced physiological function was also significantly better than the dacarbazine group (18% and 42% after 3 months of treatment, respectively). Melanoma is a rare skin tumor that accounts for only about 4% of all skin cancers, but the mortality rate accounts for about 79% of all skin cancers, and dacarbazine is the standard drug currently in use. Temozolomide has shown considerable clinical efficacy in refractory gliomas and melanomas and is worthy of attention.

 

 

 

COA:

 

 

Test items

 

Requirements

Results

 

Description

 

A White or off-white crystalline powder; odorless; tasted bitter.

Complies

 

Solubility

 

Slightly soluble in water, very slightly soluble in dehydrated alcohol, soluble in DMF and very soluble DMSO.

Complies

 

Identification

 

 

 

A. IR

 

A: Conform to reference standard

Conforms

 

B. Chemical Property

 

B: Dissolve 0.1g the sample with 10ml water, add 5ml dinitro-phenyl-hydrazine, should have marron precipitate.

Positive

 

C. HPLC

 

C: The retention time of the major peak in the chromatogram of the assay preparation corresponds to that in the chromatogram of the standard preparation

Conforms

 

Loss on drying

 

≤ 1.0%.

0.21%

 

Residue on ignition

 

≤ 0.1%.

0.07%

 

Heavy metals

 

≤ 0.002%.

Complies

 

Chloride

 

≤ 0.002%.

Complies

 

Impurities by HPLC
Any impurity(Max)
Total impurities

 


≤ 0.1%.
≤ 0.3%.


0.042%
0.08%

 

Residual solvents
Ethyl acetate
Alcohol
DMSO

 


≤ 0.5%.
≤ 0.5%.
≤ 0.5%.


Complies
Complies
Complies

 

Assay (HPLC)

 

98.5%~102.0%

99.80%

 

Anti Cancers Powder Active Pharmaceutical Ingredient Temozolomide CAS 85622-93-1 1

 

OUR ADWANTAGE:


1, High quality with competitive price:
1) Standard: U.S Standard
2) All Purity≥99.8%
3) We are manufacturer and can provide high quality products with factory price.


2, Fast and safe delivery
1) Parcel can be sent out within 8 hours after payment. Tracking number available
2) Secure and discreet shipment. Various transportation methods for your choice.
3) Customs pass rate ≥99.8%
4)We provide re-ship policy.
5) We have warehouse in Australia, Canada and England, we have large amounts of stock in the warehouse, can ship to you directly from our foreign warehouse!
3, We have clients throughout the world.
1) Professional service and rich experience make customers feel at ease, adequate stock and fast delivery meet their desire.
2) Meeting customers's requirement is our responsibility.
3) High quality, competitive price, fast delivery, first-class service gain the trust and praise from the customers.

 

 

Our Commitment:

 

1. Quality assurance

With our years of experience, advanced technology and continuous research, our quality is to fully meet the needs of the market to meet the requirements of customers, many customers use our products, we believe that the product is very good. Whether it is a powder, or liquid, yes, we all know, our liquid better.

 

 

2. Safe transportation

Our mode of transport is taken according to each country's situation is different transportation, while our packaging, according to the latest customs situation, constantly updated, improved our packaging, we guarantee that you receive it within 3-5 to your product.

 

 

3. The product diversity

Our products are powders and liquids, yes, brothers, the effect of the liquid is very good, but many people do not use liquid, so you are very lucky, you buy our powder, we can tell you the method of making the liquid If you buy a liquid, we will tell you how to filter. We absolutely guarantee that you can very safely use our products

 

 

4. High quality service

Our goods packing will not contain any hormone information and can be sent out from different areas of china. At present,the goods customs clearance rate we send to United states and Europe is 99%, As for Canada, Brazil of quite high buckle close rate area, we also have a new way to get through the customs. We also have completely re-send policy to some areas.

 

 

How to Complete an Order:

 

 

Make an order

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3.We send the detail price of our product and offer the suitable shipping method for reference;

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5.We arrange the shipment according to your requirements.

6.We offer after-sales service after you receive parcel.

Shipping

Provide your addressee info. ( phone number , zip code )

Packing

According to different countries and quantity of orders

Lead Time

Arranged within 12 hours upon receipt of your payment

Photos

Photos of parcel would be offered to tell apart the steroids in advance

Delivery Time

Usually 4-6 working days to reach destinations

Tracking number

Offered once it is released on the Net .Normally within 24hours upon the receipt of payment.

After-sale service

24/7 online for problems and concern related product

 

 

Steroid Hormone Powder:

 

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Methenolone Series

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CAS.No

Product Name

CAS.No

Testosterone Enanthate

315-37-7

Methenolone Enanthate

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Testosterone

58-22-0

Methenolone Acetate

434-05-9

Testosterone Acetate

1045-69-8

Oral Steroids

Testosterone Propionate

57-85-2

Product Name

CAS.No

Testosterone Cypionate

58-20-8

Oxymetholone (Anadrol)

434-07-1

Testosterone Phenylpropionate

1255-49-8

Oxandrolone (Anavar,Oxandrin)

53-39-4

Testosterone Isocaproate

15262-86-9

Stanozolol(winstrol)

10418-03-8

Testosterone Decanoate

5721-91-5

Methandienone (Dianabol)

72-63-9

Testosterone Undecanoate

5949-44-0

SARMS

Sustanon 250

 

Product Name

CAS.No

Nandrolone Series

Cardarine (GW-501516)

317318-70-0

Product Name

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Andarine (S4)

401900-40-1

Nandrolone

434-22-0

Ligandrol (LGD-4033)

1165910-22-4

Nandrolone Decanoate

360-70-3

Ibutamoren (MK-677)

159752-10-0

Nandrolone phenylpropionate

62-90-8

RAD140

118237-47-0

Trenbolone Series

SR9009

1379686-30-2

Product Name

CAS.No

YK11

431579-34-9

Trenbolone

10161-33-8

Ostarine (MK-2866)

841205-47-8

Trenbolone Acetate

10161-34-9

Sex Enhancement

Trenbolone Enanthate

10161-33-8

Product Name

CAS.No

Boldenone Series

Tadalafil (Cialis)

171596-29-5

Product Name

CAS.No

Sildenafil citrate

171599-83-0

Boldenone

846-48-0

Vardenafil

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Boldenone undecylenate

13103-34-9

hydrochloride

119356-77-3

DEHA

Dutasteride (Avodart)

164656-23-9

Product Name

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Finasteride

98319-26-7

Epiandrosterone

481-29-8

Yohimbine HCl (Extract)

65-19-0

Dehydroisoandrosterone (DHEA)

53-43-0

Pain Killer

Dehydroisoandrosterone 3-acetate

853-23-6

Product Name

CAS.No

7-Keto-dehydroepiandrosterone

566-19-8

Phenacetin

62-44-2

Drostanolone Series

Benzocaine

1994/9/7

Product Name

CAS.No

Lidocaine HCL

23239-88-5

Drostanolone Propionate

521-12-0

Paracetamol

103-90-2

Drostanolone Enanthate

472-61-1

Dimethocaine

136-47-0

Methasterone

3381-88-2

Dyclonine HCL

854056-07-6

 

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Andro Test 450

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Cutting Blend 175

Tri Deca 300

Anomass 400

Rip Blend 375

TMT Blend 250

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Pentadex300

   

 

Testosterone acetate

BP

32 mg

Testosterone Deconoate

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147 mg

Testosterone propionate

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73 mg

Testosterone phenylpropionate

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73 mg

Testosterone Cypionate

BP

125 mg

Benzyl Alchohol

BP

2%

Benzyl Benzoate

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15%

Grape Seed Oil

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q.s.

 

Anti Cancers Powder Active Pharmaceutical Ingredient Temozolomide CAS 85622-93-1 0

Name: Temozolomide 85622-93-1

Appearance:white powder

Cas No:85622-93-1

EINECS:NA

Formula:C6H6N6O2

Molecular Weight:194.15

Melting Point:212.0 °C

Boiling Point: 526.6 °C

Flash Point: 272.3 °C

Usage:antineoplastics

Testing Items

Standards:Enterprise

Appearance

A white to light pinkish white crystalline powder

Identification

should conform

Loss on drying

NMT0.5%

Residual on ignition

NMT0.1%

Heavy metals

NMT10ppm

Related substances

AICA: NMT0.15%

DIAZO:NMT0.15%

other single impurity:NMT0.1%

Total Unknown Impurities:NMT0.2%

Total Impurities:NMT0.5%

Microbial limits

Bacterial Counts:NMT1000/g

Fungi and yeasts:NMT100/g

E.Coli: Should be negative

Assay(by HPLC)

98.0% ~102.0%
 

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