API Pharmaceutical Raw Materials White Powder Ibuprofen CAS 15687-27-1 For Antipyretic Analgesi

Basic Information
Place of Origin: CHINA
Brand Name: TINGYI
Certification: GMP , ISO 9001:2008
Model Number: CAS: 15687-27-1
Minimum Order Quantity: 10g
Price: Contact Us
Packaging Details: Stealth and discreet packaging
Delivery Time: Usually within 7 work days
Payment Terms: Bank Transfer - Bitcoin - Western Union - MoneyGram
Supply Ability: 3000KG/Month
Product Name: Ibuprofen Purity: 99%
CAS: 15687-27-1 MF: C13H18O2
MW: 206.28 Appearance: White To Off-white Crystalline Powder
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High Quality Pharmaceutical Ingredient Ibuprofen CAS: 15687-27-1 for Antipyretic Analgesia 

 

Product Name: Ibuprofen

 

Product Details: 

 

Product Name: Ibuprofen

Synonym: alpha-(4-isobutylphenyl)propionicacid;alpha-(p-isobutylphenyl)propionic acid;alpha-2-(p-Isobutylphenyl)propionic acid;alpha-methyl-4-(2-methylpropyl)-benzeneaceticaci;alpha-p-isobutylphenylpropionicacid;Andran;Anflagen;Artril 300

CAS: 15687-27-1

MF: C13H18O2

MW: 206.28

EINECS: 239-784-6

Melting Point: 77-78?°C(lit.)

Boiling point: 157 °C (4 mmHg)

Density: 1.0364 (rough estimate)

Refractive index: 1.5500 (estimate)

Storage: 20C Freezer

Solubility: Practically insoluble in water, freely soluble in acetone, in methanol and in methylene chloride. It dissolves in dilute solutions of alkali hydroxides and carbonates.

Acidity coefficient (pKa): pKa 4.45± 0.04(H2O,t = 25±0.5,I=0.15(KCl))(Approximate)

Appearance: White to off-white Crystalline Powder

Water solubility: insoluble

Merck: 14,4881

Stability: Stable. Combustible. Incompatible with strong oxidizing agents

 

 

 

Product Name

 

Ibuprofen

Chemical Name

2-(4-Isobutylphenyl)propanoic Acid;α-Methyl-4-(isobutyl)phenylacetic acid;(±)-2-(4-Isobutylphenyl)propanoic acid;4-Isobutyl-alpha-methylphenylacetic Acid

 

Other Name

 

Brufen,Emodin,Motrin,Rurana

 

CAS

 

15687-27-1

 

MF

 

C13H18O2

 

MW

 

206.28

 

EINECS

 

239-784-6

 

Assay

 

98%min

Appearence

White crystalline powder. Melting point 75-77. Insoluble in water, soluble in ethanol, chloroform, ether, acetone. Have a different smell, tasteless. Soluble in sodium hydroxide or sodium carbonate solution.

 

Drug category

 

Nervous system drugs-anti migraine drugs

Purpose

Antipyretic analgesic, anti-inflammatory, analgesic and antipyretic effects, suitable for the treatment of rheumatic arthritis, rheumatoid arthritis, osteoarthritis, ankylosing spondylitis and neuritis

 

 

Description:

 

Ibuprofen, also known as ibuprofen, is a non-steroidal anti-inflammatory analgesic. Its anti-inflammatory, analgesic and antipyretic effects are good and the adverse reactions are small. It has been widely used in the world and has become one of the best-selling over-the-counter drugs in the world. Together with aspirin and paracetamol, it is listed as the three pillar products of antipyretic and analgesic drugs. In China, it is mainly used for pain relief and anti-rheumatic, but it is not used in colds and fevers, far less than paracetamol and aspirin.

 

Ibuprofen was discovered by Dr. Stewart Adams (later became a professor and awarded the British Empire Medal) and his team led by research scientist CoLin Burrows and chemist John Nicholson. The original study was designed to invent a "super aspirin" to obtain an alternative to rheumatoid arthritis that is as effective as aspirin but has fewer serious adverse effects. Other drugs, such as phenylbutazone, are at high risk of agranulocytosis; corticosteroids, when used at a dose slightly higher than the usual prescription, cause adrenal suppression and other adverse reactions such as gastrointestinal ulcers. High risk of waiting. Adams decided to look for a drug with good gastrointestinal tolerance, a feature that is especially important for all current non-steroidal anti-inflammatory drugs. Phenyl acetate has attracted interest. Although some of these drugs have been shown to cause ulceration in dog tests, Adams realized that this phenomenon may be due to the long half-life of drug clearance. One of these drugs, ibuprofen, has a relatively short half-life of only 2 hours. Among the alternative medicines screened, although not the most effective, it is the safest. In 1964, ibuprofen became the most promising alternative to aspirin.

 

Ibuprofen belongs to a class of drugs called nonsteroidal anti-inflammatory drugs (NSAIDs). Other members of this class include aspirin, naproxen (Aleve), indomethacin (Indocin), nabumetone (Relafen) and several others. These drugs are used for the management of mild to moderate pain, fever, and inflammation. Pain, fever, and inflammation are promoted by the release in the body of chemicals called prostaglandins. Ibuprofen blocks the enzyme that makes prostaglandins (cyclooxygenase), resulting in lower levels of prostaglandins. As a consequence, inflammation, pain and fever are reduced. The FDA approved ibuprofen in 1974.

 

Application:

 

It has anti-inflammatory, analgesic and antipyretic effects. The efficacy of rheumatoid arthritis and rheumatoid arthritis is slightly lower than that of acetylsalicylic acid and phenylbutazone. Suitable for the treatment of rheumatoid arthritis, rheumatoid arthritis, osteoarthritis, ankylosing spondylitis and neuritis. The product ranked 13th in the 1985 US drug sales ranking.

 

Alleviate the symptoms of rheumatoid arthritis, osteoarthritis, spondyloarthropathy, gouty arthritis, rheumatoid arthritis and other chronic arthritis or persistent joint swelling and pain, no cause treatment and control course The role.

Treatment of non-articular soft tissue rheumatic pain, such as shoulder pain, tenosynovitis, bursitis, myalgia and post-exercise injury pain.

Acute mild to moderate pain such as: after surgery, post-traumatic, strain, primary dysmenorrhea, toothache, headache and so on.

It has antipyretic effect on fever in adults and children.

 

Indomethacin is commonly used as a prescription medication to treat fever, analgesic or inflammation caused by many conditions such as arthritis, gout, ankylosing spondylitis, bursitis, rheumatism, or tendinitis.
Indometacin works by reducing the production of prostaglandins, Prostaglandins are chemicals that the body produces and which cause the fever and pain that are associated with inflammation. Indometacin is similar to ibuprofen (Motrin) and naproxen (Naprosyn, Aleve).

 

COA:

 

 

Product Name

 

Ibuprofen

Standard

USP36

 

ITEMS

 

SPECIFICATIONS

RESULTS

 

Characteristics

 

White crystalline powder

Conforms

 

Solubility

 

Practically insoluble in water ;very soluble in

alcohol , in methanol ,

in acetone, and in chloroform; slightly

soluble in ethyl acetate

Conforms

 

Identification
AIR

B.UV

C.HPLC

 

a. Sample IR spectrum corresponds to

that of the standard

Conforms

B. Sample UV spectrum does not differ from

that of the standard by

more than 3.0%

Conforms

C. Retention time corresponds to that of the standard

Conforms

 

Water Content

 

not more than1.0% ≤1.0%

0.10%

 

Heavy Metals

 

not more than0.002% ≤0.002%

<0.002%

 

Residual on Ignition

 

not more than0.5% ≤0.5%

0.01%

Chromatographic Purity

2-[3-(2-methylpropyl)phenyl]propanic acid :not more than0.15%

0.02%

2-[4-methyl phenyl]propanic acid :not more than0.15%

0.0%

2-[4-ethyl phenyl]propanic acid :not more than0.15%

0.02%

2-[4-propylphenyl]propanic acid :not more than0.15%

0.01%

2-[4-butylphenyl]propanic acid :not more than0.1%

0.0%

Any unknown impurities not more than 0.05%

0.03%

Total impurities :not more than 0.6%

0.08%

 

4-Isobutylacetophenone

 

Not more than 0.1%

0.0%

 

Assay(dried basis)

 

97.0%-103.0%

99.9%

 

Residualsolvents
(Petroleum ether)

 

Not more than 250ppm

38ppm

 

ADDITIONAL TESTS

 

 

Bulk Density

 

0.20-0.50g/ml

0.33g/ml

 

Tapped density

 

0.40-0.70g/ml

0.55g/ml

 

Median particle size

 

30-60um

51.2um

 

Conclusion

 

The product meets USP36 specifications

 

API Pharmaceutical Raw Materials White Powder Ibuprofen CAS 15687-27-1 For Antipyretic Analgesi 0

 

Our commitment:

 

1. Quality assurance

With our years of experience, advanced technology and continuous research, our quality is to fully meet the needs of the market to meet the requirements of customers, many customers use our products, we believe that the product is very good. Whether it is a powder, or liquid, yes, we all know, our liquid better.

 

 

2. Safe transportation

Our mode of transport is taken according to each country's situation is different transportation, while our packaging, according to the latest customs situation, constantly updated, improved our packaging, we guarantee that you receive it within 3-5 to your product.

 

 

3. The product diversity

Our products are powders and liquids, yes, brothers, the effect of the liquid is very good, but many people do not use liquid, so you are very lucky, you buy our powder, we can tell you the method of making the liquid If you buy a liquid, we will tell you how to filter. We absolutely guarantee that you can very safely use our products

 

 

4. High quality service

Our goods packing will not contain any hormone information and can be sent out from different areas of china. At present,the goods customs clearance rate we send to United states and Europe is 99%, As for Canada, Brazil of quite high buckle close rate area, we also have a new way to get through the customs. We also have completely re-send policy to some areas.

 

 

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Make an order

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5.We arrange the shipment according to your requirements.

6.We offer after-sales service after you receive parcel.

 

Shipping

 

Provide your addressee info. ( phone number , zip code )

 

Packing

 

According to different countries and quantity of orders

 

Lead Time

 

Arranged within 12 hours upon receipt of your payment

 

Photos

 

Photos of parcel would be offered to tell apart the steroids in advance

 

Delivery Time

 

Usually 4-6 working days to reach destinations

 

Tracking number

 

Offered once it is released on the Net .Normally within 24hours upon the receipt of payment.

 

After-sale service

 

24/7 online for problems and concern related product

 

 

Our Company Advantages:

 

1, High quality with competitive price:

1) Standard: U.S Standard
2) All Purity≥99.8%
3) We are manufacturer and can provide high quality products with factory price.


2, Fast and safe delivery
1) Parcel can be sent out within 8 hours after payment. Tracking number available
2) Secure and discreet shipment. Various transportation methods for your choice.
3) Customs pass rate ≥99.8%
4)We provide re-ship policy.
5) We have warehouse in Australia, Canada and England, we have large amounts of stock in the warehouse, can ship to you directly from our foreign warehouse!
3, We have clients throughout the world.
1) Professional service and rich experience make customers feel at ease, adequate stock and fast delivery meet their desire.
2) Meeting customers's requirement is our responsibility.
3) High quality, competitive price, fast delivery, first-class service gain the trust and praise from the customers.

 

 

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