High Purity Pharmaceutical Grade Antidepressant Drug Raw Powder Tianeptine Phosphate

Basic Information
Place of Origin: CHINA
Brand Name: TINGYI
Certification: GMP , ISO 9001:2008
Model Number: Tianeptine Phosphate
Minimum Order Quantity: Negotiation
Price: Contact Us
Packaging Details: Stealth And Discreet Packaging
Delivery Time: Within 7 Work Days
Payment Terms: Bank Transfer - Bitcoin - Western Union - MoneyGram
Supply Ability: 100 KG/Month
Product Name: Tianeptine Phosphate Appearance: White Powder
Purity: 99% Min Shipping Method: EMS, HKEMS, FEDEX, DHL, UPS, Aramex, ETC
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High Purity Pharmaceutical Grade Antidepressant Drug Raw Powder Tianeptine Phosphate

 

Tianeptine Phosphate

 

 

Medical Application

1. Its main function is to facilitate serotonin reuptake. According to a study done in rats, changes were noticed when tianeptine was administered like serotonin levels increased in the hippocampus area which doesn't usually happen to other tricyclic anti-depressant drugs.

2. Furthermore, it is also considered to be a nootropic agent for it has neuroprotective effects. Based on the recent studies, tianeptine prevents and reverse stress-induced neural damage leading to the survival of neurons and synaptic plasticity promotion. Therefore, tianeptine helps one to handle a stressful situation. Also, it has the ability to improve concentration therefore helping those with very short attention spans and poor focus.

3. Also, it lessens stress-induced apoptosis or self-cell destruction, specifically in the hippocampus. In the hippocampus, tianeptine has the ability to avoid overstimulation of glutamate (AMPA and kainite type) receptors that controls the entry of Ca2+ inthe nerve cells for too much Ca2+ means toxic.

4. It is a newly discovered antidepressant agent and at the same time anti-anxiety, but haven't seen any psychotomimetic (tending to produce symptoms like those of a psychosis) side effects especially on the brain and it has a very low tendency of abuse compared to other anti-depressant drugs but almost same efficacy which was proven in a study conducted in Italy.

5. Due to its being tricyclic (contains fused three-ring moiety), it is considered to be analgesic, (pain reliever) to the extent that it can be used in chronic pain and intestinal pain as well.

6. According to a rat study, it resulted to be used as energy booster. When the rats were given Tianeptine, their swimming time raised and it is also discovered to have some effects on the pathogenesis of metabolic syndrome (multiple risk conditions like increased blood pressure, too much body fat, high cholesterol level, high blood sugar level leading to heart disease, stroke and others.

7. Also, it is discovered to have higher bioavailability compared to other tricyclic agents.

8. Based on a human study conducted in Brazil, comparing tianeptine and placebo for depressed outpatients or with bipolar disorder, it was found out that tianeptine has higher response rate which also corresponds to the findings of other European studies.

 

 

Specification

 

Product Name Tianeptine sodium
Batch No. 160625 Mfg. date 2016-6-25
Test Date 2016-6-25 Exp. date 2018-6-24
Tests Specifications Results
Description White to yellowish powder, very hygroscopic. Off-white powder, very hygroscopic.
Solubility Freetly soluble In water and methanol and dichloromethane Complies
Identification (1)By IR, To match with working standard Complies
(2)It gives reaction of sodium Complies
Impurities A ≤0.1% Not detected
Related compounds Any impurity ≤0.1% <0.1%
Total impurities ≤0.4% 0.25%
Residual Solvents Acetidin≤ 0.5% Not detected
Dichloromethane≤ 0.06% Not detected
Methanol≤ 0.3% Not detected
Acetone ≤ 0.5% Not detected
Acetonitrile≤0.041% Not detected
Ethanol≤0.5% 0.04%
N, N-dimethylformamide≤0.088% Not detected
Water ≤ 5.0% 1.38%
Assay 99.0%-101.0%(On anhydrous basis) 99.98%
Conclusion Conform to EP8.0

 

 

Excretion

Tianeptine Sulfate is excreted much more slowly than Tianeptine Sodium, meaning it remains active within the body for a longer duration.


 

Hygroscopicity

One of the main downsides to Tianepine Sodium is its ability to clump after exposure to normal conditions.
Tianeptine Sulfate does not absorb moisture from the air, and remains as a powder - making it much easier to work with.

 


Stability

Tianeptine Sodium is not stable in atmospheric moisture, and is very light sensitive, degrading quickly when exposed. Tianeptine Sulfate is much more stable, with much less light degradation.

Taste:
The taste of Tianeptine Sodium has been described as "bitter" and reportedly "tastes like death".
Tianeptins Sulfate, on the other hand, has very little taste at all.


 

Funstion

Improving Memory


mproving the brain function


Preventing and treating senile dementia


Enhancing the learning ability


Increasing the attention


Relieving the anxiety

Tianeptine sulphate is an improved salt of Tianeptine.

It is not hygroscopic so handling the powder is a lot easier. Since it is not as readily absorbed and excreted from the body, the sulfate salt allows for a more controlled release of the Tianeptine over longer periods. Rather than having to dose three times with rapid peak effects and rapidly falling effects, the sulfate salt allows for one dose to maintain plasma levels in the body much longer than the sodium salt. These improved characteristics make Tianeptine Sulfate a novel addition.


Longer lasting
Based on chemical structure and recent online reviews, the Sulphate form of Tianeptine has a

Longer duration.
This is caused, in part, by a slower rate of absorption.

More stability
Unlike Tianeptine Sodium, the Sulphate form is not hygroscopic, meaning itdoes not absorb moisture from the air.
Furthermore, it is more stable when exposed to light.

Preferred
From the preliminary online discussions, Tianeptine Sulphate is preferred among users.
It is likely to replace Tianeptine Sodium in time, due to favorable pharmacodynamics.

 

 

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