99% Lapatinib CAS 231277-92-2 targeting breast cancer drug Yellow powder

Basic Information
Place of Origin: CHINA
Brand Name: TINGYI
Certification: GMP , ISO 9001:2008
Model Number: 231277-92-2
Minimum Order Quantity: 10g
Price: Negotiable ( Discounts For Big Order )
Packaging Details: Stealth And Discreet Packaging
Delivery Time: Within 7 Working Days
Payment Terms: Bank Transfer - Bitcoin - Western Union - MoneyGram
Supply Ability: 12 KG/Month
Product Name: Lapatinib CAS: 231277-92-2
Appearance: Yellow Powder Shipping Method: EMS, HKEMS, FEDEX, DHL, UPS, Aramex, ETC
Grade Standard: Medicine Grade Purity: 99%
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                                   99%	Lapatinib CAS 231277-92-2 targeting breast cancer drug Yellow powder 0

 

Lapatinib

 

         

                       

Product Name: Lapatinib
Synonyms: lapatinib;n-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[(2-methylsulfonylethylamino)methyl]-2-furyl]quinazolin-4-amine;4-Quinazolinamine, N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[[[2-(methylsulfonyl)ethyl]amino]methyl]-2-furanyl]-;Lapatinib(TINIBS);Lapatinib Base N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[[[2-(methylsulfonyl)ethyl]amino]methyl]-2-furanyl]-4-Quinazolinamine;N-(3-chloro-4-((3-fluorobenzyl)oxy)phenyl)-6-(5-(((2-(methylsulfonyl)ethyl)amino)methyl)furan-2-yl)quinazolin-4-amine;4-[[3-Chloro-4-(3-fluorobenzyloxy)phenyl]amino]-6-[5-[[(2-methanesulfonylethyl)amino]methyl]furan-2-yl]quinazoline;GSK572016
CAS: 231277-92-2
MF: C29H26ClFN4O4S
MW: 581.0575432
EINECS: 1806241-263-5
Lapatinib Structure
 
 
Lapatinib Usage And Synthesis
Indications and Usage Lapatinib is a drug targeting breast cancer developed by British GlaxoSmithKline Co.
Human ErbB receptors belong to the type I tyrosine kinase (TK) receptor family, including ErbB1 (EGFR), ErbB2 (HER2), ErbB3 (HER3), and ErbB4 (HER4). The ErbB-1 (EGFR) and ErbB-2 (HER-2) receptors are often overexpressed or otherwise altered in cancer patients. Human epidermal growth factor receptor 2 (ErbB-2, HER-2) is known to be a human oncogene closely related with breast cancer. Its high expression in breast cancer often predicts lymph node metastasis and poor tumor differentiation, with poor prognosis. HER-2 is one of the target molecules for breast cancer-specific therapy. Lapatinib can act simultaneously on both Her-1 Her-2. The biological effects of this method inhibiting the proliferation and growth of tumor cells are much larger than only acting on one target. The combination of Lapatinib with Capecitabine is used to treat patients with advanced or metastatic breast cancer with overexpression of human epidermal receptor2, already treated with anthracyclines, paclitaxel, and trastuzumab. Clinical trials have shown that Lapatinib also effectively treats HER2-type cancer patients with Herceptin resistance.
Mechanisms of Action Lapatinib is a tyrosine kinase inhibitor which can effectively inhibit the tyrosine kinase activity of human epidermal growth factor receptors 1 and 2 (ErbB1, ErbB2). It can uniquely act in a variety of ways, ensuring that breast cancer cells cannot receive growth signals. It inhibits intracellular EGFR (ErbB-1) and HER2 (ErbB-2) ATP sites, preventing tumor cell phosphorylation and activation, blocking down-regulation signals through the homogeneity and heterogeneity of EGFR (ErbB-1) and HER2 (ErbB-1) dimerization.
Uses Lapatinib Ditosylate (GW572016, GW2016, Tykerb, Tyverb) is a potent EGFR and ErbB2 inhibitor with IC50 of 10.8 and 9.2 nM, respectively.
Uses Lapatinib, used in the form of Lapatinib Ditosylate, is a potent EGFR and ErbB2 inhibitor with IC50 of 10.8 and 9.2 nM, respectively.
Uses antineoplastic, tyrosine kinase inhibitor
Uses An antineoplastic agent used in breast cancer research

 

 

__________________________ For Your Reference ______________________________
Place of origin : China
Certificate : ISO9001:2008, KOSHER, GMP, SGS
Quality Standard : USP
Minimum Order Quantity : 10 g
Production Capacity : 1000 Kg/Month

_____________________________ Package & Delivery ______________________________
Package : Foil bag, Foil tin , Drum or as your request
Payment Method : T/T, Western Union, MoneyGram
Shipping Method : EMS, DHL, FeDex, UPS
Leading time : Within 48 hours after confirming payment
Delivery time : Within 7 working days after confirming payment

______________________________ Why Choose Us ? ______________________________
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