99% High Purity Local Anesthetic Raw Powder Proparacaine HCL CAS 5875-06-9

Basic Information
Place of Origin: CHINA
Brand Name: GSP
Certification: GMP , ISO 9001:2008
Model Number: 5875-06-9
Minimum Order Quantity: 100g
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Packaging Details: Stealth And Discreet Packaging
Delivery Time: Within 7 Working Days
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Supply Ability: 100 KG/Month
Product Name: Proparacaine Hydrochloride Synonyms: Proparacaine HCL
CAS: 5875-06-9 Appearance: White Powder
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99% High Purity Local Anesthetic Raw Powder Proparacaine HCL CAS 5875-06-9 0
 

Proparacaine Hydrochloride

 


Product Name: Proparacaine hydrochloride
Synonyms: 2-(Diethylamino)ethyl 3-amino-4-propoxybenzoate monohydrochloride;2-[(3-amino-4-propoxyphenyl)-oxomethoxy]ethyl-diethylammonium chloride;Proparacaine hydrochloride, >=99%;PROPARACAINE HCL;PROPARACAINE HYDROCHLORIDE;3-amino-4-propoxybenzoicacid2-(diethylamino)ethylesterhydrochloride;alcaine;benzoicacid,3-amino-4-propoxy-,2-(diethylamino)ethylester,hydrochloride
CAS: 5875-06-9
MF: C16H27ClN2O3
MW: 330.85
EINECS: 227-541-7
Melting point 182.0-183.3℃

Usage: Anesthetic;Neuronal conductance inhibitor

 

 

DESCRIPTION:

Proparacaine Hydrochloride Ophthalmic Solution USP, 0.5% is a local anesthetic for ophthalmic instillation. Each mL of sterile, aqueous solution contains: Active: Proparacaine Hydrochloride 5 mg (0.5%). Inactives: Glycerin as a stabilizer, Hydrochloric Acid and/or Sodium Hydroxide may be added to adjust pH (3.5 to 6.0), and Water for Injection. Preservative: Benzalkonium Chloride 0.1 mg (0.01%).

Proparacaine hydrochloride is designed chemically as 2-(Diethylamino)ethyl 3-amino-4-propoxybenzoate monohydrochloride. The active ingredient is represented by the structural formula:

 


CLINICAL PHARMACOLOGY:
Proparacaine Hydrochloride Ophthalmic Solution is a rapid acting local anesthetic suitable for ophthalmic use. With a single drop, the onset of anesthesia begins within 30 seconds and persists for 15 minutes or longer.

The main site of anesthetic action is the nerve cell membrane where Proparacaine interferes with the large transient increase in the membrane permeability to sodium ions that is normally produced by a slight depolarization of the membrane. As the anesthetic action progressively develops in a nerve, the threshold for electrical stimulation gradually increases and the safety factor for conduction decreases; when this action is sufficiently well developed, block of conduction is produced.

The exact mechanism whereby Proparacaine and other local anesthetics influence the permeability of the cell membrane is unknown; however, several studies indicate that local anesthetics may limit sodium ion permeability by closing the pores through which the ions migrate in the lipid layer of the nerve cell membrane. This limitation prevents the fundamental change necessary for the generation of the action potential.

 


INDICATIONS AND USAGE:
Proparacaine Hydrochloride Ophthalmic Solution is indicated for topical anesthesia in ophthalmic practice. Representative ophthalmic procedures in which the preparation provides good local anesthesia include measurement of intraocular pressure (tonometry), removal of foreign bodies and sutures from the cornea, conjunctival scraping in diagnosis and gonioscopic examination; it is also indicated for use as a topical anesthetic prior to surgical operations such as cataract extraction.

 

 

 

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