High Purity White Powder Pharmaceutical Raw Materials Paroxetine CAS: 61869-08-7 for Antidepressant
Product details:
Product Name: Paroxetine
Synonym: 3-((1,3-benzodioxol-5-yloxy)methyl)-4-(4-fluorophenyl)-,(3s,4r)-piperidin;3α-(1,3-Benzodioxole-5-yloxymethyl)-4β-(4-fluorophenyl)piperidine;3α-[(1,3-Benzodioxol-5-yl)oxymethyl]-4β-(4-fluorophenyl)piperidine;(3S,4R)-3-[(2H-1,3-benzodioxol-5-yloxy)Methyl]-4-(4-fluorophenyl)piperidine;Paroxetine HCl anhydrous API;Paloxitene;Piperidine,3-[(1,3-benzodioxol-5-yloxy)Methyl]-4-(4-fluorophenyl)-, (3S,4R)-;(3S,4R)-3-((benzo[d][1,3]dioxol-5-yloxy)methyl)-4-(4-fluorophenyl)piperidine
CAS: 61869-08-7
MF: C19H20FNO3
MW: 329.37
EINECS: 682-717-4
Related categories: API; pharmaceutical raw materials; psychotropic therapeutics; drugs; central nervous system drugs; Fluorobenzene; APIs; Paroxetine; Inhibitors; Intermediates & Fine Chemicals; Isotope Labeled Compounds; Pharmaceuticals; API's
Melting Point: 114-116°C
Density: 1.1844 (estimate)
Appearance: white powder
Description:
Paroxetine (paxil), the scientific name of flufeniperate, is a phenyl piperidine compound developed by GlaxoSmithKline and marketed in 1991. It has a highly selective 5-HT reuptake retardation, and its antidepressant effect is similar to that of tricyclic antidepressants (TCAs), and the side effects are significantly smaller than tricyclic antidepressants (TCAs). A new antidepressant drug.
Paroxetine Hydroehloride: C19H20FNO3?HCI. Tiny flaky crystals, melting point 118 ° C. Paroxetine Hydrochloride Hemihydrate: C19H20FN03?HCI?1/2H2O. Crystallization, melting point 129 ~ 131 ° C. Paroxetine Maleate: C19H20FNO3?C4H4O4. Crystallized from ethanol-diethyl ether, melting point 136-138 °C. [α] D-87° (C=5, ethanol). Acutely toxic LD50 mice (mg/kg): 845 subcutaneous injections, 500 orally.
Application:
Used as an antidepressant. It can strongly and selectively inhibit the reabsorption of serotonin by synaptosomes without directly interfering with any central neurotransmitter receptor. Used for depression, especially anxiety and obsessive-compulsive disorder.
Production Method:
Method 1: Compound (I) and Compound (II) are condensed in the presence of dicyclohexylcarbodiimide (DCC) to give paroxetine.
Method 2: After converting the compound (I) to the mesylate, it is reacted with the sodium salt of the compound (II) to obtain paroxetine.
Method 3: Compound (III) or another N-alkyl substituted compound was dissolved in toluene, and (1-chloroethyl) chloroformate was added at 15 ° C over 15 min. After the addition, stir for 18 h. Methanol was added and stirred for another 12 hours. The solvent was removed, and the residue was dissolved in hot isopropanol, treated with activated carbon and alumina, and filtered. Water was added to the filtrate, and the precipitate precipitated was collected by filtration to obtain paroxetine hydrochloride hemihydrate in a yield of 92%.
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