Vinpocetine 42971-09-5 Cerebrovascular Expansion Nootropics Drug 99% Assay

Basic Information
Place of Origin: CHINA
Brand Name: TINGYI
Certification: GMP , ISO 9001:2008
Model Number: 42971-09-5
Minimum Order Quantity: 10g
Price: Contact Me
Packaging Details: Disguised Package
Delivery Time: 2 Working Days
Payment Terms: Bank Transfer - Bitcoin - Western Union - MoneyGram
Supply Ability: 100 KG/Month
Product Name: Vinpocetine CAS: 42971-09-5
Appearance: White Powder Usage: Nootropics Drug
Shipping Method: EMS, HKEMS, FEDEX, DHL, UPS, Aramex, ETC Color: White
High Light:

pharmaceutical active ingredients

,

pharmaceutical fine chemicals

Product Details

Product Name Vinpocetine
CAS 42971-09-5
MF C22H26N2O2
MW 350.45
EINECS 256-028-0
Molecular Structure Vinpocetine 42971-09-5 Cerebrovascular Expansion Nootropics Drug 99% Assay 0
Appearence White powder
Purity 99%
Melting Point 147-153 °C dec.
Density 1.28 g / cm3
Boiling point 419.5ºC at 760 mmHg
Storage Shading, sealing, in a cool place to save.

Vinpocetine 42971-09-5 Cerebrovascular Expansion Nootropics Drug 99% Assay 1

COA

 

Items

Specification

Results
appearance White or slightly yellow, crystalline powder White crystalline
Solubility Practically insoluble in water, soluble in methylene chloride, slightly soluble in anhydrousethanol confirms
Identification (IR)

same wave numbers as that of the Vinpocetine, CRS similarly prepared

CRS similarly prepared.

Conforms
Specific Optical Rotation(On dried basis) Between +127° and +134° +132.7°
Related Substances (External Standard method)
Ethyl vincaminate(A) ≤0.6% Conforms
Apovincamine(B) ≤0.5% Conforms
Methoxyvinpocetine(C) ≤0.3% Not detected
Dihydrovinpocetine(D) ≤ 0.5% Not detected
Other single impurity ≤0.10% Conforms
Total impurity ≤ 1.0% 0.19%

Loss on drying

≤ 0.5% 0.04%

Sulphated ash

≤ 0.1% 0.07%
Assay(On dried basis) 98.5% ~101,5% , 100.2%

 

 

Description

 

       Vinpocetine is a derivative of Vincamine, which is extracted from the Periwinkle plant ( Vinca Minor, Vinca Pervinca ). Research suggests that Vinpocetine helps to maintain healthy blood circulation in the brain and supports certain neurotransmitters in the memory process. Vinpocetine supports and protects brain blood vessel health and aids mental function.

 

       (1) Vinpocetine is a cerebrovascular expansion drug and has a relatively stronger function than Vincamine. It can selectively increase cerebral blood flow, enhance and improve brain oxygen supply, promote metabolism, enhance the capacity of deformation for red blood cells, reduce blood viscosity, inhibit platelet aggregation, improve tissue metabolism.
 

       (2) Vinpocetine is mainly used in the treatment of cerebral infarction sequela, cerebral hemorrhage sequelae, cerebral arteriosclerosis, etc. It can also used in the treatment of retinal vascular sclerosis and blood vessel spasm, the elderly deafness, and dizziness.
 

       (3) Vinpocetine is a half synthetic Vincamine derivative, and has the similar effect with Vincamine. It has a stronger expansion function for cerebrovascular selectively.

 

 

 

Recommend Dosage 

 

       Take Vinpocetine with meals to enhance absorption.
       The standard low dose is 5mg of Vinpocetine at each of these three meals, with 20mg per meal seen as a high dose. This dose range is suitable for the purposes of neuroprotection, enhancing cerebral blood flow, and reducing the rate of cognitive decline.

 

 

 

Side Effects


       IV administration of Vinpocetine can cause serious adverse effects, such as death from sudden falls in blood pressure and heart rate (R, R2). However, this is not an issue with oral Vinpocetine at the standard dosages.
There have been reports of skin allergy to vincamine (R).
There was also one report of a sudden drop in white blood cell count at 15mg per day (R).


 


Uses

 

       In alternative medicine, vinpocetine is used for a variety of conditions. So far, scientific support for the potential benefits of vinpocetine is lacking.

 

1) Stroke and Vascular Dementia

       According to some alternative medicine practitioners, vinpocetine may help to increase blood circulation in the brain. Some preliminary studies suggest that it may reduce brain impairment and dementia after an ischemic stroke.

 

2) Alzheimer's Disease

       Vinpocetine is being explored as a complementary treatment for people with Alzheimer’s disease. It’s thought to enhance the brain's use of oxygen, protect brain cells against damage, and increase blood flow to the brain possibly by inhibiting an enzyme called phosphodiesterase.
       A critical review of previously published studies found that the evidence as a whole was too weak to rely on, due to limitations in the design of the studies. Further research is needed.

 

3) Tinnitus

       Studies suggest that vinpocetine may help with tinnitus after trauma to the ear.

4) Cognitive Function

       Vinpocetine is marketed in North America as a supplement that can boost memory and brain function in healthy people, but there is no real evidence yet that it can help.

Vinpocetine 42971-09-5 Cerebrovascular Expansion Nootropics Drug 99% Assay 2

 

Vinpocetine 42971-09-5 Cerebrovascular Expansion Nootropics Drug 99% Assay 3

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