Pramoxine HCL 637-58-1 Local Anesthetic Drug 99% Assay Quick Effect Raw Powder

Basic Information
Place of Origin: CHINA
Brand Name: TINGYI
Certification: GMP , ISO 9001:2008
Model Number: 637-58-1
Minimum Order Quantity: 10g
Price: Contact Me
Packaging Details: Disguised Package
Delivery Time: 2 Working Days
Payment Terms: Bank Transfer - Bitcoin - Western Union - MoneyGram
Supply Ability: 100 KG/Month
Product Name: Pramoxine HCL CAS: 637-58-1
Appearance: White Powder Usage: Local Anesthetic
Shipping Method: EMS, HKEMS, FEDEX, DHL, UPS, Aramex, ETC Color: White
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Quick Details

Product name Pramoxine hydrochloride
 Alias Pramoxine hcl
CAS 637-58-1
MF C17H28ClNO3
MW 329.86
Apperance White solid
Assay 99%
Grade Pharmaceutical grade
Delivery time Within 12h after your payment
Packing Discreet package for delivery guarantee!
Delivery terms EMS, HKEMS, FEDEX, DHL, UPS, Aramex, ETC
Payment Western Union, MoneyGram, Bank Transfer, Bitcoin, Litecoin

 

 

 

Pramoxine Hydrochloride Description


         Pramoxine Hydrochloride is a topical anesthetic and used as an antipruritic too. Chemical name is p-n butoxyphenyl gammamorpholinopropyl ether hydrochloride. During research, Pramoxine Hydrochloride stood out among a series of alkoxy aryl alkamine ethers as an especially great topical local anesthetic agent. Pharmacologic study revealed Pramoxine Hydrochloride to be very potent and of low acute toxicity, well tolerated by most mucous membranes and of a low sensitizing index. Pramoxine Hydrochloride reduces the permeability of neuronal membranes to sodium ions, blocking initiation and conduction of nerve impulse. Depolarization and repolarization of excitable neural membranes is thus inhibited by Pramoxine Hydrochloride, leading to the numb sensation.


       The high potency and low acute and sub-acute toxicity of Pramocaine have popularized its usage in over-the-counter itching creams and sunburn lotions. It may also be used in treating rectal irritations. The drug is sometimes administered in a spray or wipe form.


       Pramocaine works by lowering the permeability of neuron membranes to sodium ions. This blocks the initiation and conduction of the nerve impulses that cause sensations of pain. The application of Pramocaine is usually prescribed 3-4 times daily. Although allergic reactions are uncommon, they may sometimes manifest in the form of dryness, burning, stinging, bleeding, hives, skin rash, itching and swelling. This medication should be stored in an airtight container out of reach of children.

 

 


Application


       Topical anesthetics are used to relieve pain and itching caused by conditions such as sunburn or other minor burns, insect bites or stings, poison ivy, poison oak, poison sumac, and minor cuts and scratches. Pramocaine and dibucaine are also common ingredients in over the counter hemorrhoid preparations.


        Anesthesia, local- Proparacaine and tetracaine are indicated to produce local anesthesia of short duration for ophthalmic procedures including measurement of intraocular pressure, removal of foreign bodies and sutures, and conjunctival and corneal scraping in diagnosis and gonioscopy. Proparacaine hydrochloride and tetracaine are also indicated to produce local anesthesia prior to surgical procedures such as cataract extraction and pterygium excision, usually as an adjunct to locally injected anesthetics. Ophthalmic solutions used for intraocular procedures should be preservative-free. Preservatives may cause damage to the corneal epithelium if a significant quantity of solutionenters the eye through the incision.

 

 

 

COA

 

Melting range 170~174°C 171.7~173.2°C
Loss on drying ≤1.0% 0.12%
Residue on ignition ≤0.1% 0.04%
Ethanol ≤0.5% 0.061%
Carbinol ≤0.3% 0.10%
Acetone ≤0.5% Not detected
Assay 98.0%~102.0% 99.98%
Conclusion The results conforms with USP33

Pramoxine HCL 637-58-1 Local Anesthetic Drug 99% Assay Quick Effect Raw Powder 0

Pramoxine HCL 637-58-1 Local Anesthetic Drug 99% Assay Quick Effect Raw Powder 1

 

 

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