Mepivacaine HCL 1722-62-9 Local Anesthetic Raw Powder Quick Effect 99% Assay

Product Details

Product Name	Mepivacaine HCL
CAS NO	1722-62-9
Alias	Mepivacaine Hydrochloride
MF	C15H23ClN2O.CIH
MW	282.80900
MS
Customized	Non-Customized
Availability	Adult
Pure	Content99%
Appearance	White Crystalline Powder
Origin	China
Certification	ISO 9001, ISO 14001, GMP
State	Powder
Usage	Local anesthesia
Qulification	USP/BP/EP/JP/CP
Apperance	white Powder

COA

Description

       Mepivacaine Hydrochloride, a tertiary amine used as a local anesthetic, is 1-methyl-2', 6' - pipecoloxylidide monohydrochloride. Mepivicaine hydrochloride is a local anesthetic of the amide type. Mepivicaine as a reasonably rapid onset and medium duration and is known by the proprietary names as Carbocaine and Polocaine. Mepivicaine is used in local infiltration and regional anesthesia.

        Systemic absorption of local anesthetics produces effects on the cardiovascular and central nervous systems. At blood concentrations achieved with normal therapeutic doses, changes in cardiac conduction, excitability, refractoriness, contractility, and peripheral vascular resistance are minimal.

        Mepivacaine Hydrochloride is actually a very simple combination of two B vitamins, PAPA (P-aminobenzoic acid) and DEAE (diethylaminoethanol) buffered and stabilized with benzoic acid and potassium metabisulfite for more effectiveness inside the body. Procaine hydrochloride is a compound combination of PABA and DEAE, a vitaminic substance first synthesized in 1905 by a German chemist, Dr. Albert Einhorn, who was looking for a simple, non-addictive anesthetic.

         For years procaine was used as a simple anesthetic, but soon researchers began to notice other curative powers of this substance. Interest in experimentation ran so high that between 1930 and 1951, over 165 reports were published on the effects of procaine in the treatment of a variety of conditions including arthritis, neuralgia, itching, peptic ulcer, asthma and hypertension. In the late 1940's three French physicians - Drs. Ghali, Boudon, and Guoit - found that procaine hydrochloride helped relieve suffering from asthma attacks. Dr. Rene Leriche discovered that procaine injections were helpful in treating certain forms of arthritis, arteritis, and blood clots in the limbs.

Applications

       Mepivacaine hydrochloride to stabilize the neuronal membrane, to prevent the occurrence and spread of nerve impulses, and thus local anesthesia.

       The rapid metabolism of mepivacaine hydrochloride, only a small part of the anesthetic (5% to 10%) excretion in the urine unchanged. Methapine is not detoxified by circulating plasma esterase because of its amide structure. The liver is the main site of metabolism, more than 50% of the dose as a metabolite is excreted into the bile. Most metabolized mepivacaine may be absorbed in the intestine and then excreted into the urine because only a small fraction is found in the feces.

        The main way to excrete is through the kidneys. Most anesthetics and their metabolites are eliminated within 30 hours. It has been shown that hydroxylation and N-demethylation as detoxification play an important role in the metabolism of anesthetics. Three metabolites of mepivacaine have been identified from adults: two phenols are almost completely excreted as glucuronide conjugates, and N-demethylated compounds.

        Local anesthetics block the generation and the conduction of nerve impulses, presumably by increasing the threshold for electrical excitation in the nerve, by slowing the propagation of the nerve impulse, and by reducing the rate of rise of the action potential. In general, the progression of anesthesia is related to the diameter, myelination, and conduction velocity of affected nerve fibers. Clinically, the order of loss of nerve function is as follows: pain, temperature, touch, proprioception, and skeletal muscle tone.

Half life

       The half-life of mepivacaine in adults is 1.9 to 3.2 hours and in neonates 8.7 to Mepivacaine hydrochloride of action.

        Local anesthetics block the generation and the conduction of nerve impulses, presumably by increasing the threshold for electrical excitation in the nerve, by slowing the propagation of the nerve impulse, and by reducing the rate of rise of the action potential. In general, the progression of anesthesia is related to the diameter, myelination, and conduction velocity of affected nerve fibers. Clinically, the order of loss of nerve function is as follows: pain, temperature, touch, proprioception, and skeletal muscle tone.

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