Flumazenil FMZ 78755-81-4 Nervous System Drug Quick Effect 99% Purity

Basic Information
Place of Origin: CHINA
Brand Name: TINGYI
Certification: GMP , ISO 9001:2008
Model Number: 78755-81-4
Minimum Order Quantity: 10g
Price: Contact Me
Packaging Details: Disguised Package
Delivery Time: 2 Working Days
Payment Terms: Bank Transfer - Bitcoin - Western Union - MoneyGram
Supply Ability: 100 KG/Month
Product Name: Flumazenil CAS: 78755-81-4
Appearance: White Powder Usage: Nervous System Drug
Shipping Method: EMS, HKEMS, FEDEX, DHL, UPS, Aramex, ETC Synonym: FMZ
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pharmaceutical active ingredients

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pharmaceutical fine chemicals

Flumazenil Basic Information

Product Name Flumazenil
Alias Romazicon
CAS 78755-81-4
MF C15H14FN3O3
MW 303.29
MS Flumazenil FMZ 78755-81-4 Nervous System Drug Quick Effect 99% Purity 0
Purity 99%
Grade Pharmaceutical Grade
Brand Nmae Tingyi
Standard USP
Stock Mass Stock
Shelf Life 2years
Packing Methods foil bag or as your mind
Delivery time within 12 hours after payment confirmed
Payment Western Union,Money Gram , Bank TransferBitcoin, Litecoin
Usage Fumazenil is an imidazobenzodiazepine derivative.
Fumazenil a potent benzodiazepine receptor antagonist.

 

 

COA

 

Items of analysis Specification Results
Appearance White crystalline powder White Crystalline Powder
Identification The sample's IR spectrum is according with spectrum of Flumazenil,The retention time of the major peak Flumazenil in the chromatogram of the Assay preparation corresponds to that in the chromatogram of the Standard preparation Conforms
Melting point 198ºC to 202ºC 200.6ºC to 200.9ºC
Appearance of solution The solution is clear and is not Intenser than reference solution BY7 Conforms
Impurity C NMT 0.2% 0.02%
Impurity A NMT 0.10% Not detected
Impurity B NMT 0.2% 0.03%
Impurity D NMT 0.10% 0.03%
Impurity E NMT 0.10% Not detected
Impurity F NMT 0.10% Not detected
Individual unknown impurituy NMT 0.10% 0.02%
Total impurities NMT 0.5% 0.1%
Loss on drying NMT 0.5% 0.2%
Sulphated ash NMT 0.1% 0.05%
Heavy metals ≤0.5 ppm 5ppm
Microbial limits
(for Injection)
Bacteria not more than 50CFU/g <10 CFU/g
Microbial limits Mildew and microzyme not more than 50CFU/g <10 CFU/g
Microbial limits Escherichia coli absence Absence
Ethanol NMT2000ppm Not detected
Chloroform NMT30ppm Not detected
Acetic acid NMT4000ppm Not detected
Dichloromethane NMT600ppm <0.002%
Ethyl ethanoate NMT5000ppm <0.003%
DMF NMT750ppm Not detected
Assay (On dried substance) 98.0-102.0% 99.80%
Bacterial endotoxins not more than 25.0 USP Endotoxin Units per mg of flumazenil. not more than 8.0 USP Endotoxin Units per mg of flumazenil.
Guarantees the nature time 36 months 36 months

 

 

Flumazenil benefits and effects


(1)Flumazenil is of benefit in patients who become excessively drowsy after benzodiazepine are used for either diagnostic or therapeutic procedures.


(2)It has been used as an antidote in the treatment of benzodiazepine overdoses. There are many complications that must be taken into consideration when used in the acute care setting.These include lowered seizure threshold, agitation, and anxiousness. Flumazenil's short half-life requires multiple doses and careful patient monitoring to prevent recurrence of overdose symptoms.

 

(3)Flumazenil has been effectively used to treat overdoses of non-benzodiazepine hypnotics, such as zolpidem, zaleplon and zopiclone.

 


Flumazenil Half life


Initial distribution half-life is 4 to 11 minutes and the terminal half-life is 40 to 80 minutes. Prolongation of the half-life to 1.3 hours in patients with moderate hepatic impairment and 2.4 hours in severely impaired patients. Compared to adults, the elimination half-life in pediatric patients was more variable, averaging 40 minutes (range: 20 to 75 minutes).

Flumazenil FMZ 78755-81-4 Nervous System Drug Quick Effect 99% Purity 1

Flumazenil FMZ 78755-81-4 Nervous System Drug Quick Effect 99% Purity 2

 

 

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