| Place of Origin: | CHINA |
|---|---|
| Brand Name: | TINGYI |
| Certification: | GMP , ISO 9001:2008 |
| Model Number: | 78755-81-4 |
| Minimum Order Quantity: | 10g |
| Price: | Contact Me |
| Packaging Details: | Disguised Package |
| Delivery Time: | 2 Working Days |
| Payment Terms: | Bank Transfer - Bitcoin - Western Union - MoneyGram |
| Supply Ability: | 100 KG/Month |
| Product Name: | Flumazenil | CAS: | 78755-81-4 |
|---|---|---|---|
| Appearance: | White Powder | Usage: | Nervous System Drug |
| Shipping Method: | EMS, HKEMS, FEDEX, DHL, UPS, Aramex, ETC | Synonym: | FMZ |
| High Light: | pharmaceutical active ingredients,pharmaceutical fine chemicals |
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Flumazenil Basic Information
| Product Name | Flumazenil |
| Alias | Romazicon |
| CAS | 78755-81-4 |
| MF | C15H14FN3O3 |
| MW | 303.29 |
| MS |  |
| Purity | 99% |
| Grade | Pharmaceutical Grade |
| Brand Nmae | Tingyi |
| Standard | USP |
| Stock | Mass Stock |
| Shelf Life | 2years |
| Packing Methods | foil bag or as your mind |
| Delivery time | within 12 hours after payment confirmed |
| Payment | Western Union,Money Gram , Bank TransferBitcoin, Litecoin |
| Usage | Fumazenil is an imidazobenzodiazepine derivative. Fumazenil a potent benzodiazepine receptor antagonist. |
COA
| Items of analysis | Specification | Results |
| Appearance | White crystalline powder | White Crystalline Powder |
| Identification | The sample's IR spectrum is according with spectrum of Flumazenil,The retention time of the major peak Flumazenil in the chromatogram of the Assay preparation corresponds to that in the chromatogram of the Standard preparation | Conforms |
| Melting point | 198ºC to 202ºC | 200.6ºC to 200.9ºC |
| Appearance of solution | The solution is clear and is not Intenser than reference solution BY7 | Conforms |
| Impurity C | NMT 0.2% | 0.02% |
| Impurity A | NMT 0.10% | Not detected |
| Impurity B | NMT 0.2% | 0.03% |
| Impurity D | NMT 0.10% | 0.03% |
| Impurity E | NMT 0.10% | Not detected |
| Impurity F | NMT 0.10% | Not detected |
| Individual unknown impurituy | NMT 0.10% | 0.02% |
| Total impurities | NMT 0.5% | 0.1% |
| Loss on drying | NMT 0.5% | 0.2% |
| Sulphated ash | NMT 0.1% | 0.05% |
| Heavy metals | ≤0.5 ppm | 5ppm |
| Microbial limits (for Injection) |
Bacteria not more than 50CFU/g | <10 CFU/g |
| Microbial limits | Mildew and microzyme not more than 50CFU/g | <10 CFU/g |
| Microbial limits | Escherichia coli absence | Absence |
| Ethanol | NMT2000ppm | Not detected |
| Chloroform | NMT30ppm | Not detected |
| Acetic acid | NMT4000ppm | Not detected |
| Dichloromethane | NMT600ppm | <0.002% |
| Ethyl ethanoate | NMT5000ppm | <0.003% |
| DMF | NMT750ppm | Not detected |
| Assay (On dried substance) | 98.0-102.0% | 99.80% |
| Bacterial endotoxins | not more than 25.0 USP Endotoxin Units per mg of flumazenil. | not more than 8.0 USP Endotoxin Units per mg of flumazenil. |
| Guarantees the nature time | 36 months | 36 months |
Flumazenil benefits and effects
(1)Flumazenil is of benefit in patients who become excessively drowsy after benzodiazepine are used for either diagnostic or therapeutic procedures.
(2)It has been used as an antidote in the treatment of benzodiazepine overdoses. There are many complications that must be taken into consideration when used in the acute care setting.These include lowered seizure threshold, agitation, and anxiousness. Flumazenil's short half-life requires multiple doses and careful patient monitoring to prevent recurrence of overdose symptoms.
(3)Flumazenil has been effectively used to treat overdoses of non-benzodiazepine hypnotics, such as zolpidem, zaleplon and zopiclone.
Flumazenil Half life
Initial distribution half-life is 4 to 11 minutes and the terminal half-life is 40 to 80 minutes. Prolongation of the half-life to 1.3 hours in patients with moderate hepatic impairment and 2.4 hours in severely impaired patients. Compared to adults, the elimination half-life in pediatric patients was more variable, averaging 40 minutes (range: 20 to 75 minutes).
Related Nervous System Drug
| Oxcarbazepine |
| Atropine |
| Pregabalin |
| Flumazenil |
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| Amlodipine |
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| Clozapine |
| NSI-189 |
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