| Place of Origin: | CHINA |
|---|---|
| Brand Name: | TINGYI |
| Certification: | GMP , ISO 9001:2008 |
| Model Number: | 191217-81-9 |
| Minimum Order Quantity: | 10g |
| Price: | Contact Me |
| Packaging Details: | Disguised Package |
| Delivery Time: | 2 Working Days |
| Payment Terms: | Bank Transfer - Bitcoin - Western Union - MoneyGram |
| Supply Ability: | 100 KG/Month |
| Product Name: | Pramipexole | CAS: | 191217-81-9 |
|---|---|---|---|
| Appearance: | White Powder | Usage: | Nervous System Drug |
| Shipping Method: | EMS, HKEMS, FEDEX, DHL, UPS, Aramex, ETC | Color: | White |
| High Light: | pharmaceutical anabolic steroids,pharmaceutical fine chemicals |
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Basic Information
| Product Name | Pramipexole |
| CAS | 191217-81-9 |
| Purity | 99% |
| Molecular Formula | C10H21Cl2N3OS |
| Molecular Weight | 302.26 |
| Molecular Structure |  |
| Payment Method | Western Union, Bank Transfer, MoneyGram, Bitcoin, Litecoin |
Descriptions
Pramipexole dihydrochloride monohydrate is new-generation non-ergot dopamine receptor agonist, which can avoid nervous lesion caused by long-term use of levodopa, delay levodopa treatment time, and reduce the dosage of levodopa. Moreover, the drug can be applied to D2/D3 receptors selectively, thus controlling sports-related symptoms like tremor, easing psychic symptoms and treating Parkinson’s disease.
According to in-vitro study, Pramipexole has relatively-high specificity for D2 receptor and complete intrinsic activity, and higher affinity for D3 receptor than that for D2 and D4 receptors.
The interaction of Pramipexole and D3 receptor and its correlation with Parkinson’s disease are indefinite. Definite mechanism for Pramipexole’s treating Parkinson’s disease is unclear. According to current opinion, it is related to dopamine receptor of activated corpus striatum. According to animal electricity physiological test, Pramipexole can influence the discharge frequency of corpus striatum neuron through activating corpus striatum and nigral dopamine receptor.
Applications
Treating the signs and symptoms of Parkinson disease. It is also used to treat restless legs syndrome (RLS).: Pramipexole is a non-ergoline dopamine agonist indicated for treating early-stage Parkinson's disease (PD) and restless legs syndrome (RLS). It is also sometimes used off-label as a treatment for cluster headache and to counteract the problems with sexual dysfunction experienced by some users of the selective serotonin reuptake inhibitor (SSRI) antidepressants.
Pramipexole has shown robust effects on pilot studies in a placebo-controlled proof of concept study in bipolar disorder. It is also being investigated for the treatment of clinical depression and fibromyalgia. It may also be used for other conditions as determined by your doctor.Pramipexole is a dopamine agonist. Exactly how pramipexole works is not known. It may increase the action of certain chemical receptors in the brain.
To alleviate the symptoms of Parkinson's disease: Parkinson's disease is due to the movement of brain dopaminergic neuron loss caused by dopamine deficiency, lead to patients with tremor, rigidity and bradykinesia and a series of symptoms. Hydrochloric acid highly selective effects on dopamine D2 and D3 receptor agonist, dopamine release, improve motor symptoms.
Research on Shannon display, early Parkinson's disease patients pramipexole monotherapy after, can effectively control the motor symptoms in patients with early stage, to help maintain the ability of daily life. Pramipexole in combination with levodopa can effectively improve the ADL score and motor symptoms in patients with advanced Parkinson's disease score in patients with advanced Parkinson's disease, make life more vibrant.
Specifications
| Item | Standard | Result |
| Appearance | White or colorless crystalline powder | conforms |
| Salicylic acid | 99.0%-100.5% min | 99.56% |
| Melting point | 158-161°C | 159.5°C |
| Clarity and color of solution | Clear and colorless | conforms |
| Heavy Mntals | 20ppm | conforms |
| Chloride | 100ppm | conforms |
| Loss on drying | 0.5% max | 0.06% |
| Sulfate Ash | 0.1%max | 0.03% |
| Sulfate | 200ppm | Conforms |
Effect
The effect of Pramipexole on the D3 receptor has a strong impact on the neurological system, which is why it's used to treat Parkinson's disease and in some cases Alzheimer's disease. Through acting on the D3 receptor, Pramipexole also affects a man's sexual interest and activity. Prolactin is in part directly responsible for a man's refractory period, which refers to the time it takes to recover from sexual activity so that performance can occur again. By lowering prolactin through an increase in dopamine, Pramipexole can directly reduce the refractory period resulting in the ability to perform sexually more frequently.
Do NOT use pramipexole if
you are allergic to any ingredient in pramipexole
you are taking another medicine that has pramipexole in it
Contact your doctor or health care provider right away if any of these apply to you.
How to proceed an order
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