Xylazine hydrochloride Nervous System Drug 99% Assay 23076-35-9 Quick Effect

Basic Information
Place of Origin: CHINA
Brand Name: TINGYI
Certification: GMP , ISO 9001:2008
Model Number: 23076-35-9
Minimum Order Quantity: 10g
Price: Contact Me
Packaging Details: Disguised Package
Delivery Time: 2 Working Days
Payment Terms: Bank Transfer - Bitcoin - Western Union - MoneyGram
Supply Ability: 100 KG/Month
Product Name: Xylazine Hydrochloride CAS: 23076-35-9
Appearance: White Powder Usage: Nervous System Drug
Shipping Method: EMS, HKEMS, FEDEX, DHL, UPS, Aramex, ETC Color: White
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pharmaceutical active ingredients

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pharmaceutical fine chemicals


Basic Information

Product Name Xylazine hydrochloride
CAS 23076-35-9
Purity 99%
Molecular Formula C12H17ClN2S
Molecular Weight 256.79
Molecular Structure Xylazine hydrochloride Nervous System Drug 99% Assay 23076-35-9 Quick Effect 0
Payment Method Western Union, Bank Transfer, MoneyGram, Bitcoin, Litecoin
 
 
 
COA
Product name  

Xylazine Hydrochloride

 

 

CAS No.

 

23076-35-9

 

Outer Packing

 

1KG

 

Production date

 

2018.04.07

 

Shelf life

 

2 years

Standard adopted  

USP39

Items of analysis Specification Results
Appearance White to almost white crystalline hygroscopic powder White crystalline hygroscopic powder
Identification

A: IR absorption

B: Thin-layer chromatographic identification test

Conforms
 

Loss of drying

NMT 1.0% 0.35%
Melting range 164 ℃ -168 ℃  

165.4-166.5℃

Heavy metals

NMT 20ppm <20ppm
Residue on ignition NMT 0.1% 0.03%
Ph 4~6 4.9
Chromatographic Total impurities: NMT2.0% Conforms
Solution clarity Meet the requirement(CP Standard) Conforms
Toluene NMT890ppm Conforms
Ethanol NMT5000ppm Conforms
N-Butyl alcohol NMT5000ppm Conforms
Assay Not less than 98.0% and not more than 102.0% 99.42%

Conclusion

Qualified

 

 

 

 

Description


Xylazine hydrochloride, a non-narcotic compound, is a sedative and analgesic as well as a muscle relaxant. Its sedative and analgesic activity is related to central nervous system depression. Following intramuscular administration, the clinical effects of xylazine hydrochloride are apparent within 10-15 minutes. Clinical effects are observed within 3-5 minutes of intravenous administration. A sleeplike state, the depth of which is dose-dependent, is usually maintained for 1 to 2 hours, while analgesia lasts from 15 to 30 minutes.


Xylazine is an analogue of clonidine and an agonist at the α2 class of adrenergic receptor. It is used for sedation, anesthesia, muscle relaxation, and analgesia in animals such as horses, cattle and other non-human mammals.

 

In veterinary anesthesia, xylazine is often used in combination. It is sold under many brand names worldwide, most notably the Bayer brand name Rompun.It is also marketed as Anased, Sedazine, and Chanazine. The drug interactions vary with different animals.


Results from early human clinical studies confirmed that xylazine has several central nervous system depressant effects. Xylazine administration is used for sedation, anesthesia, muscle relaxation, and analgesia. It causes a significant reduction in blood pressure and heart rate in healthy volunteers.

 

 

 

Application


Xylazine dose-dependently inhibits norepinephrine release and lipolysis in beagle dogs. Xylazine also tends to decrease epinephrine levels dose-dependently. Xylazine hydrochloride dose- and time-dependently reduces amount of minimum alveolar concentration (MAC) in horse. Xylazine hydrochloride dose- and time-dependently increases blood glucose concentration in horse. Xylazine induces variable bilateral caudal analgesia extending from coccyx to S3, with minimal sedation, ataxia, and cardiovascular and respiratory depression in standing mares. Xylazine significantly decreases heart and respiratory rates, systolic, diastolic, and mean arterial blood pressure, PCV, hemoglobin concentration, arterial oxygen content, and oxygen transport.

 

Xylazine results in significantly decreased heart rate, increased incidence of atrioventricular block, and decreased cardiac output and cardiac index in horse. Xylazine induces sedation and selective (S3 to Co) analgesia for at least 2 hours in cows. Xylazine significantly decreases heart rate, respiratory rate, rate of ruminal contractions, arterial blood pressure, PaO2, PCV, and total solids concentration, and significantly increases PaCO2, base excess, and bicarbonate concentration in cows. Xylazine severely depresses the N3 field (-75%) and completely abolishes the climbing fiber field (-100%) in the nonanesthetized, decerebrated rat. Xylazine- ketamine injections also severely depresses the N3 field (-75%) and nearly completely abolishes theclimbing fiber field (-90%) in the nonanesthetized, decerebrated rat.

 

 

 

Pharmacology


(1)Xylazine HCl Injection (xylazine), a non-narcotic compound, is a sedative and analgesic as well as muscle relaxant. Its sedative and analgesic activity is related to central nervous system depression. Its muscle relaxant effect is based on inhibition of the intraneural transmission of impulses in the central nervous system. The principal pharmacological activities develop within 10 to 15 minutes after intramuscular injection in horses and Cervidae, and within 3 to 5 minutes following intravenous administration in horses.


(2)A sleeplike state, the depth of which is dose-dependent, is usually maintained for 1 to 2 hours, while analgesia lasts from 15 to 30 minutes. The centrally-acting muscle relaxant effect causes relaxation of the skeletal musculature, complementing sedation and analgesia.


(3)In horses and Cervidae under the influence of Xylazine HCl Injection (xylazine), the respiratory rate is reduced as in natural sleep. Following treatment with Xylazine HCl Injection (xylazine), the heart rate is decreased and a transient change in the conductivity of the cardiac muscle may occur, as evidenced by a partial atrioventricular block. This resembles the atrioventricular block often observed in normal horses. Partial A-V block may occasionally occur following intramuscular injection of Xylazine HCl Injection (xylazine). When given intravenously in horses, the incidence of partial A-V block is higher. Intravenous administration causes a transient rise in blood pressure in horses, followed by a slight decrease.

 

 

 

Function


Xylazine is an analogue of clonidine and an agonist at the α2 class ofadrenergic receptor.

Xylazine is used for sedation, anesthesia, muscle relaxation, and analgesia in animals such as horses, cattle and other animals. Veterinarians also use xylazine as an emetic, especially in cats.


- Central nervous system inhibitors, analgesic muscle relaxants, non-narcotic sedatives
- Assist enhanced effect on most anesthetics

 

 

Medical uses


Xylazine is often used as a sedative, muscle relaxant, and analgesic. It is frequently used in the treatment of tetanus. Xylazine is very similar to drugs such as phenothiazine, tricyclic antidepressants, and clonidine. As an anesthetic, it is typically used in conjunction .Xylazine appears to reduce sensitivity to insulin and glucose uptake in humans.Yohimbine has been used to decrease glucose levels to a healthy level. In clinical settings, Yohimbine can reverse the adverse effects of xylazine if administered intravenously at a dosage of 0.5 mL / 20 pounds shortly after xylazine administration.

 

 

 

Dosage


Xylazine can be administered intravenously, intramuscularly, subcutaneously or orally. The commercial product contains 23.32 mg/ml xylazine hydrochloride in water based injectable solution. Xylazine can be obtained also as pure crystalline powder. There is a significant species dependent response to xylazine administration. Intramuscular dose of up to 0.3 mg/kg for cattle has been suggested by the manufacturer. The recommended doses for horses were 0.6 mg/kg and for sheep 1.0 mg/kg. For dogs the dose was even higher.Xylazine is an analogue of clonidine and an agonist at the α2 class of adrenergic receptor. It is used for sedation, anesthesia, muscle relaxation, and analgesia in animals such as horses, cattle and other non-human mammals. Veterinarians also use xylazine as an emetic, especially in cats.

Xylazine hydrochloride Nervous System Drug 99% Assay 23076-35-9 Quick Effect 1

Xylazine hydrochloride Nervous System Drug 99% Assay 23076-35-9 Quick Effect 2

 

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