Reserpine 50-55-5 Nervous System Drug USP Standard Lower Blood Pressure 99% Assay

Basic Information

Product Name	Reserpine
CAS	50-55-5
Purity	99%
Molecular Formula	C33H40N2O9
Molecular Weight	608.68
Molecular Structure
Payment Method	Western Union, Bank Transfer, MoneyGram, Bitcoin, Litecoin

Introduction

      Reserpine is extracted from the root of Rauwolfia serpentinaor Rauwolfia vomitoria, plants found in India and Africa. Intraditional herbal medicine, the root was brewed as a tea andused in humans to treat hypertension, insanity, snakebite, andcholera. Reserpine was the first drug found to interfere withthe human sympathetic nervous system, and it initiated theeffective pharmacotherapeutic control of hypertension.Reserpine is a naturally occurring drug that has been used forcenturies in ancient India.

       Reserpine is an anti-adrenergic drug. Reserpineis a Postganglionic sympathetic nerve terminal blocker.Reserpine impairs the storage of biogenic amines byinterfering with an uptake mechanism. Results in depletion ofnorepinephrine, dopamine, and serotonin in both central andperipheral neurons. Reserpine reduces the cardiac output bynegative inotropic effect and negative chronotropic effect.Similarly by reducing sympathetic activity to blood vessels,Reserpine relaxes capacitance vessels and reduces totalperipheral resistance.

Application

        Reserpine is an indole alkaloid, antipsychotic and antihypertensive drug that has been used for the control of high blood pressure and for the relief of psychotic symptoms, although because of the development of better drugs for these purposes and because of its numerous side-effects, it is rarely used today. The antihypertensive actions of reserpine are a result of its ability to deplete catecholamines (among other monoamine neurotransmitters) from peripheral sympathetic nerve endings. These substances are normally involved in controlling heart rate, force of cardiac contraction and peripheral vascular resistance.

        1. Reserpine was blocked by adrenergic neurons of antihypertensive drugs.

        2. This product is the depletion of peripheral sympathetic nerve endings of adrenaline, heart, brain and other tissues of catecholamines and 5 - HT to anti-high blood pressure, slow heart rate and inhibition of the central nervous system. Antihypertensive effect primarily by reducing cardiac output and reduced peripheral resistance, part of the cardiovascular reflex inhibition to achieve.

        3. Reserpine acts on hypothalamic area produce sedation, but no cause drowsiness and anesthetic effects, does not change the sleep EEG, can ease the anxiety of patients with hypertension, tension and headaches.

        4. Experimental animal for less than the clinical dose of reserpine, which appears miosis, eyelid wrinkles and sagging, hypothermia, gastrointestinal symptoms such as the acceleration of activity.