|Place of Origin:||CHINA|
|Certification:||GMP , ISO 9001:2008|
|Minimum Order Quantity:||1KG|
|Packaging Details:||Stealth And Discreet Packaging|
|Delivery Time:||Within 7 Working Days|
|Payment Terms:||Bank Transfer - Bitcoin - Western Union - MoneyGram|
|Supply Ability:||200 KG/Month|
|Product Name:||Sodium Cyanoborohydride||CAS:||25895-60-7|
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|Product Name:||Sodium cyanoborohydride|
|Synonyms:||sodium cyanoborohydride CAS 25895-60-7 hot selling;SODIUM CYANOBOROHYDRIDE;SODIUM CYANOTRIHYDRIDOBORATE;SODIUM CYANOTRIHYDROBORATE;Sodium cyonobrohydriole;SODIUM CYANOBOROHYDRIDE, 5.0M SOLUTION I N AQUEOUS CA. 1M SODIUM HYDROXIDE;SODIUM CYANOBOROHYDRIDE, 1.0M SOLUTION I N TETRAHYDROFURAN;Sodiumcyanoborohydride,95%|
|Product Categories:||Selectivity reducing agent;B (Classes of Boron Compounds);Classes of Metal Compounds;Na (Sodium) Compounds (excluding simple sodium salts);Reduction;Synthetic Organic Chemistry;Tetrahydroborates;Typical Metal Compounds;Borohydrides;Synthetic Reagents;borane|
|Sodium cyanoborohydride Chemical Properties|
|Melting point||>242 °C (dec.)(lit.)|
|density||1.083 g/mL at 25 °C|
|storage temp.||Store under Argon|
|solubility||H2O: may be clear to slightly hazy|
|Water Solubility||2120 g/L at 29 ºC (dec.)|
|Stability:||Stable. Hygroscopic. Reacts violently with water, giving off and igniting hydrogen. Do not use water on fires involving this chemical - instead use dry soda ash. Incompatible with strong acids, water, strong oxidizing agents.|
|RIDADR||UN 3179 4.1/PG 2|
|Hazard Note||Toxic/Highly Flammable|
|Sodium cyanoborohydride Usage And Synthesis|
|Chemical Properties||White solid|
|Uses||Selective reducing agent for aldehydes, ketones, oximes, enamines; does not reduce amides, ethers, lactones, nitriles, nitro Compounds and epoxides. Also used for reductive amination of ketones and aldehydes, reductive alkylation of amines and hydrazines, reductive displacement of halides and tosylates, deoxygenation of aldehydes and ketones. See Lane, loc. cit.|
|Uses||Sodium cyanoborohydride are frequently used for reductive aminations. Since the reaction rate for the reduction of iminium ions is much faster than for ketones or even aldehydes, the reductive amination can be carried out as a one-pot procedure by introducing the reducing agent into a mixture of the amine and carbonyl compound.
Contact with strong acids liberates the highly toxic gas HCN. A safer reducing agent with comparable reactivity is sodium triacetoxyborohydride. Reduction with Sodium Cyanoborohydride:
|Purification Methods||It is avery hygroscopic solid, soluble in H2O (212% at 29o, 121% at 88o), tetrahydrofuran (37% at 28o, 42.2% at 62o), very soluble in MeOH, slightly soluble in EtOH but insoluble in Et2O, *C6H6 and hexane. It is stable to acid up to pH 3 but is hydrolysed in 12N HCl. The rate of hydrolysis at pH 3 is 10-8 times that of NaBH4. The fresh commercially available material is usually sufficiently pure. If very pure material is required, one of the following procedures can be used [Lane Synthesis 135 1975]: (a) The NaBH3CN is dissolved in tetrahydrofuran (20% w/v), filtered and the filtrate is treated with a fourfold volume of CH2Cl2. The solid is collected and dried in a vacuum [Wade et al. Inorg Chem. 9 2146 1970]. (b) NaBH3CN is dissolved in dry MeNO3, filtered, and the filtrate is poured into a 10-fold volume of CCl4 with vigorous stirring; the white precipitate is collected, washed several times with CCl4 and dried in a vacuum (yield 75%) [Berschied & Purcell Inorg Chem 9 624 1970]. (c) When the above procedures fail to give a clean product, then dissolve NaBH3CN (10g) in tetrahydrofuran (80mL) and add N MeOH/HCl until the pH is 9. Pour the solution with stirring into dioxane (250mL). The solution is filtered and heated to reflux. A further volume of dioxane (150mL) is added slowly with swirling. The solution is cooled slowly to room temperature, then chilled in ice and the crystalline dioxane complex is collected, dried in a vacuum for 4hours at 25o, then 4hours at 80o to yield the amorphous dioxane-free powder (6.7g) with purity >98% [Borch et al. J Am Chem Soc 93 2897 1971]. The purity can be checked by iodometric titration [Lyttle et al. Anal Chem 24 1843 1952].|
|Sodium cyanoborohydride Preparation Products And Raw materials|
|Preparation Products||N-METHYL-P-ANISIDINE-->1-CYCLOPROPYLPIPERAZINE-->Enalapril-->N-isopropyl-2-(piperazin-1-yl)pyridin-3-amine-->INDOLINE-6-CARBOXYLIC ACID-->4-Aminopyrimidine-->2-AMINOCYCLOHEXANECARBONITRILE-->ethyl indoline-6-carboxylate-->3-Dimethylaminophenylboronic acid-->4-N-Boc-4-N-Methyl-aminopiperidine-->Lisinopril-->1-(CYCLOPROPYLMETHYL)PIPERAZINE-->1-Boc-4-Methylaminopiperidine-->N-Boc-4-(Cyclopropylmethyl)piperazine-->tert-Butyl 4-hydrazinylpiperidine-1-carboxylate-->1-Piperonylpiperazine-->6-bromo-3,4-dihydro-3-nitro-2H-chromene-->1-(3-PYRROLIDINOPROPYL)PIPERAZINE-->7-BROMO-1,2,3,4-TETRAHYDRO-QUINOLINE HYDROCHLORIDE-->4-(1-Pyrrolidinyl)piperidine-->N,N-Dimethylpiperidin-4-amine-->NETILMICIN|
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