|Place of Origin:||CHINA|
|Certification:||GMP , ISO 9001:2008|
|Minimum Order Quantity:||10g|
|Packaging Details:||Disguised Package|
|Delivery Time:||2 Working Days|
|Payment Terms:||Bank Transfer - Bitcoin - Western Union - MoneyGram|
|Supply Ability:||100 KG/Month|
|Shipping Method:||EMS, HKEMS, FEDEX, DHL, UPS, Aramex, ETC||Color:||White|
pharmaceutical active ingredients,
pharmaceutical fine chemicals
|Payment Method||Western Union, Bank Transfer, MoneyGram, Bitcoin, Litecoin|
|Product Name||Indomethacin||MFG. Date||Jan 2019|
|Batch NO.||HS13-068||EXP. Date||Jan.2021|
|Characters||White crystalline powder ,parctically insoluble in water, sparingly soluble in alcohol||Conforms|
|B.Absorption at 318nm||170-190||185.19|
|C.||Conforms to the requirement||Conforms|
|D.||Conforms to the requirement||Conforms|
|E.||Conforms to the requirement||Conforms|
|Related substances(TLC)||Not more than 0.5%||<0.5%|
|Heavy metals||Not more than 20ppm||<20ppm|
|Loss on drying||Not more than 0.5%||0.13%|
|Sulphated Ash||Not more than 0.1%||0.07%|
|Conclusion:Complies with EP7|
Indomethacin is a kind of stronger corticoid anti-inflammatory and antipyretic and analgesic, by inhibiting cyclooxygenase reducing the synthesis of prostaglandin (PG), to prevent the formation of the nere impulses, inflammation tissue inhibiting inflammatory reaction, including inhibition of leukocyte chemotaxis and lysosomal enzyme release, etc., and produce antipyretic, analgesic and anti-inflammatory effects. Indomethacin anti-inflammatory, antipyretic effect is very strong, its anti-inflammatory effect is better than bute, 84 times better than hydrocortisone, and sugar cortical hormone, used in combination with aspirin, bute, can reduce their dosage, toxic and side effects, improve curative effect; Second is antipyretic effect, 10 times than amidopyrine ;its analgesic action is weak , only to the inflammatory pain has obvious analgesic effect, but the effect is good for inflammatory pain than Baotai loose, analgin and salicylic acid.
Clinical is mainly used for the salicylic acid, drugs are less tolerance or curative effect is not obvious in the acute and chronic rheumatic or rheumatoid arthritis, ankylosing spondylitis, slippery bursa phlogistic, tenosynovitis, articular capsulitis, osteoarthritis and acute gout and cancerous pain, etc.In recent years, the researchers try to use indomethacin biliary colic, dysmenorrhea, migraine, glomerulonephritis, polyuria, salmonella gastroenteritis, orthostatic hypotension, bart syndrome and so on, all have good curative effect.It can also be used to treat eye pigment meningitis, keratitis, scleritis, glaucoma and fever caused by cancer or other difficult to control the fever. Dermatologist for lupus erythematosus (sle), white plug syndrome, scleroderma, nodular erythema, herpes zoster, joint type of psoriasis, etc. photosensitive dermatitis induced by topical treatment of eczema, allergic dermatitis, and local pain.
Clinical indications for indometacin include
dysmenorrhea (menstrual cramps)
fever and pain associated with malignant diseases (especially tumor fever associated with liver involvement, lymphogranulomatosis)
patent ductus arteriosus
nephrogenic diabetes insipidus (prostaglandin inhibits vasopressin's action in the kidney)
Paget's disease of bone
primary stabbing headaches
renal colic (pain due to kidney stones)
retinopathy of prematurity
trigeminal autonomic cephalgias
Headaches induced by or otherwise a result of Valsalva maneuver
Indomethacin has also been used clinically to delay premature labor, reduce amniotic fluid in polyhydramnios, and to close patent ductus arteriosus.
Indomethacin is a potent drug with many serious side effects and should not be considered an analgesic for minor aches and pains or fever. The medication is better described as an anti-inflammatory, rather than an analgesic.
Usage and dosage
1. Anti-rheumatism: adult dosage: oral: early quantity from 25 to 50 mg each time, 2 ~ 4 times a day, immediately take at food service or after a meal. Such as good tolerance, the daily dosage can be increased from 25 to 50 mg per week, the most mount should not be more than 200 mg a day. Arthritis patients such as persistent pain at night or morning stiffness, can give quantity of 100 mg in bed all day.
2. Resistance to gout: oral: At the beginning quantity is 100 mg once, then 50 mg, three times a day, until the pain relief, and then gradually reduced as soon as possible, until the drug withdrawal.
3. Antifebrile: adult dosage: oral: 25 ~ 50 mg each time, 3 ~ 4 times daily.Rectal drug delivery: every time 50 mg, 50 to 100 mg per day. Pediatric dosage: oral: 0.5 ~ 1 mg/kg each time, 3 times a day.
|TUDCA (Tauroursodeoxycholic Acid)|