Promethazine HCL 58-33-3 Raw Powder 99% Assay Quick Effect USP Standard

Basic Information
Place of Origin: CHINA
Brand Name: TINGYI
Certification: GMP , ISO 9001:2008
Model Number: 58-33-3
Minimum Order Quantity: 10g
Price: Contact Me
Packaging Details: Disguised Package
Delivery Time: 2 Working Days
Payment Terms: Bank Transfer - Bitcoin - Western Union - MoneyGram
Supply Ability: 100 KG/Month
Product Name: Promethazine HCL CAS: 58-33-3
Appearance: White Powder Synonym: Atosil
Shipping Method: EMS, HKEMS, FEDEX, DHL, UPS, Aramex, ETC Color: White
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Basic Information

Product Name Promethazine HCL
CAS 58-33-3
Purity 99%
EINECS 200-375-2
Molecular Formula C17H21ClN2S
Molecular Weight 320.88
Molecular Structure Promethazine HCL 58-33-3 Raw Powder 99% Assay Quick Effect USP Standard 0
Usage For the treatment of allergic disorders, and nausea/vomiting.
Storage Store in cool and dry area and keep away from direct sunlight.
Payment Method Western Union, Bank Transfer, MoneyGram, Bitcoin, Litecoin

Promethazine HCL 58-33-3 Raw Powder 99% Assay Quick Effect USP Standard 1

 

 

COA

Product name promethazine hydrochloride
CAS No. 58-33-3 Outer Packing 25KG/DRUM
Production date APRIL 2016 Shelf life MARCH 2021
Standard adopted IP
Items of analysis Specification Results
description a white or faintly yellowish,crystalline powder a white crystalline powder
solubility very soluble in water,freely soluble in chloroform and in ethanol(95%) very soluble in water,freely soluble in chloroform and in ethanol(95%)
A. IR absorption spectrum positions and relative sizes of the banks in the spectrum positions and relative sizes of the bands in the spectrum
B.by TLC It complies with the identification test for phenothiazines it complies with the identification test for phenothiazine
C.Test with nitric acid forms orange colored solution and organge-red precipitate complies with test for chlorides
pH(10% w/v solution) 4.0-5.0 4.31
isopromethazine not more than 1.0% less than 1.0%
other impurity not more than 0.5% less than 0.5%
sulphated ash not more than 0.5% 0.20%
loss on drying at 105ºC not more than 0.5% 0.20%
assay 98.5-101%(on anhydrous basis) 100.0%
Conclusion Qualified

 

 

 

Promethazine hydrochloride Description


         Promethazine hydrochloride is a prescription drug. It's available as an oral solution, a rectal suppository, and an oral tablet.
The rectal suppositories are available as the brand-named drugs Phenadoz, Phenergan, and Promethegan. They are also available as generic drugs. The oral solution and oral tablet are only available as generic drugs. Generic drugs usually cost less. In some es, they may not be available in every strength or form as the brand-name version. This drug may be used as part of a combination therapy. This means you may need to take it with other medications.

 

 

 

DOSAGE AND ADMINISTRATION


         Promethazine Hydrochloride Tablets USP are contraindicated for children under 2 years of age (see WARNINGS-Black Box Warning and Use in Pediatric Patients).

 

1. Allergy

         The average oral dose is 25 mg taken before retiring; however, 12.5 mg may be taken before meals and on retiring, if necessary. Single 25-mg doses at bedtime or 6.25 to 12.5 mg taken three times daily will usually suffice. After initiation of treatment in children or adults, dosage should be adjusted to the smallest amount adequate. The administration of promethazine HCl (promethazine hydrochloride) in 25-mg doses will control minor transfusion reactions of an allergic nature.

 

2. Motion Sickness

        The average adult dose is 25 mg taken twice daily. The initial dose should be taken one-half to one hour before anticipated travel and be repeated 8 to 12 hours later, if necessary. On succeeding days of travel, it is recommended that 25 mg be given on arising and again before the evening meal. For children, promethazine hydrochloride tablets, syrup, or rectal suppositories, 12.5 to 25 mg twice daily, may be administered.
 

3. Nausea and Vomiting

        Antiemetics should not be used in vomiting of unknown etiology in children and adolescents (see WARNINGS-Use in Pediatric Patients). The average effective dose of promethazine hydrochloride for the active therapy of nausea and vomiting in children or adults is 25 mg. When oral medication cannot be tolerated, the dose should be given parenterally (cf. Promethazine Injection) or by rectal suppository. 12.5- to 25-mg doses may be repeated, as necessary, at 4-to 6-hour intervals.

 

        For nausea and vomiting in children, the usual dose is 0.5 mg per pound of body weight, and the dose should be adjusted to the age and weight of the patient and the severity of the condition being treated. For prophylaxis of nausea and vomiting, as during surgery and the postoperative period, the average dose is 25 mg repeated at 4- to 6-hour intervals, as necessary.


4. Sedation

        This product relieves apprehension and induces a quiet sleep from which the patient can be easily aroused. Administration of 12.5 to 25 mg promethazine hydrochloride by the oral route or by rectal suppository at bedtime will provide sedation in children. Adults usually require 25 to 50 mg for nighttime, presurgical, or obstetrical sedation.

 


Precautions


(1) pyloric obstruction, enlarged prostate, bladder neck obstruction, angle-closure glaucoma, hyperthyroidism and hypertension patients with caution.


(2) During the administration should avoid driving, handling machinery or engage in aerial work.


(3) with renal dysfunction who have a history of epilepsy with caution.


(4) children 3 months of age should not be used.


(5) can cause drowsiness, dizziness and mouth, nose, throat dry as well as abdominal pain, diarrhea, vomiting, acute poisoning. Severe poisoning can cause convulsions, followed by central inhibition. Dingjing note available at this time, avoid using central stimulants.


(6) Where the phenothiazine class of drugs required precautions are applicable to this product.


(7) light sensitization can not be reused.

Promethazine HCL 58-33-3 Raw Powder 99% Assay Quick Effect USP Standard 2

 

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