Apremilast 608141-41-9 Treat Active Psoriatic Arthritis 99% Purity Quick Effect

Basic Information
Place of Origin: CHINA
Brand Name: TINGYI
Certification: GMP , ISO 9001:2008
Model Number: 608141-41-9
Minimum Order Quantity: 10g
Price: Contact Me
Packaging Details: Disguised Package
Delivery Time: 2 Working Days
Payment Terms: Bank Transfer - Bitcoin - Western Union - MoneyGram
Supply Ability: 100 KG/Month
Product Name: Apremilast CAS: 608141-41-9
Appearance: White Powder Usage: Treat Active Psoriatic Arthritis
Shipping Method: EMS, HKEMS, FEDEX, DHL, UPS, Aramex, ETC Color: White
High Light:

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Basic Information

Product Name Apremilast
CAS 608141-41-9
Purity 99%
Molecular Formula C22H24N2O7S
Molecular Weight 460.51
Molecular Structure Apremilast 608141-41-9 Treat Active Psoriatic Arthritis 99% Purity Quick Effect 0
Payment Method Western Union, Bank Transfer, MoneyGram, Bitcoin, Litecoin
 

Description


Apremilast (Otezla) was approved by the FDA on March 21, 2014 for the treatment of adult patients with active psoriatic arthritis. Apremilast is a member of a new class of oral small molecule inhibitors of the phosphosphodiesterase 4 (PDE4) enzyme. When PDE4 is inhibited in immune cells, it results in elevation of intracellular cyclic adenosine monophosphate (cAMP) levels, which can regulate inflammatory mediators. The current clinical data indicate that apremilast is an effective and well tolerated option for the management of psoriasis and PsA in adults.

 

 


Apremilast safety information


1. Apremilast may cause depression. The risk may be greater in patients who have a history of depression or suicidal thoughts or actions. Families and caregivers must closely watch patients who take apremilast. It is important to keep in close contact with the patient's doctor. Tell the doctor right away if the patient has new, worsened, or sudden symptoms, such as depression; anxiety, restlessness, or irritability; panic attacks; or any changes in behavior. Contact the doctor right away if any signs of suicidal thoughts or actions occur.


2. Apremilast may cause weight loss. You will need to have regular weight checks while you are taking apremilast.

 

 

 

Uses


Treating active psoriatic arthritis. It is also used to treat moderate to severe plaque psoriasis in certain patients.

 

 

 

Metabolism and Drug interaction


Oral administration of apremilast has an absolute biovailability of 73% with peak concentration at 2.5 hours (Tmax). The half-life of apremilast is 6-9 hours. Apremilast is metabolized by the both cytochrome (CYP) and non-CYP pathways. In vitro studies have demonstrated that apremilast metabolism is primarily mediated by the CYP3A4 pathway. Thus, concomitant use of apremilast with CYP450 enzyme inducers (such as rifampin, phenobarbital, carbamazepine, phenytoin) is not recommended. There are no significant drug-drug interactions with oral contraceptives, ketoconazole, or methotrexate.

 

 

 

Our Competitive Advantages


1. Rich experience
Our company is a professional production leading factory in China in pharmaceutical area of many years


2. Superior quality, purity and favourable
Our company is a professional leading manufacturer in China in pharmaceutical area.Good quality is one of our secret success.

 

3. Safe and fast delivery
We have GOLDEN FORWARDER and UK Warehouse so we can delivery quickly and safely.

 

4. Package

Professional packing with professional materials.

 

5. Competitive Prices

Low price with high qulity.

 

 

 

FAQ


Q1: Have your Product Quality been Approved by Third Party Lab ?
A: Yes, All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France etc. So you will be assured with Good Quality if you choose us.


Q2. Are you a manufacturer?
A: Yes, we have our own factory and lab.

 

Q3: Is there any discount?
A: Yes, as for old customers and larger quantity, we always support with great discounts and surprise.

 

Q4:Do you accept VISA business credit card ?
A:Sorry we don't accept VISA credit card, we'd like to accept Western Union, MoneyGram, Bank Transfer, Bitcoin, Litecoin.

 

Q5: How do you treat quality complaint?
A: First of all, our QC department will do strict examination of our export products in order to reduce the quality problem to near zero. If there is a real quality problem caused by us, we will send you free goods for replacement or refund your loss.


Q6: How to proceed order?

1st: Please let me know what you need-Which product/Cas No. quantity, and the destination country.
2nd: You send us the purchase order once we come to an agreement on all details.
3rd: Parcel would be delivered upon full payment received.
4th: Express Tracking No.will be provided about the parcels.
5th: You will get the parcels within 7days.
6th: After-sales service would be provided after you receive parcels.

 

Apremilast 608141-41-9 Treat Active Psoriatic Arthritis 99% Purity Quick Effect 1

 

General Comments


We have professional team for package and shipment.Fast and secure shipment could be arranged for customs pass guaranteed.

 

Our company has independent import and export authority,also has the certificate of importing and exporting pharmaceutical materials. At the same time we are developed manufactures with mass stock.

 

 

Contact Details
Sales Manager

WhatsApp : +8613657291547