Dacomitinib 1110813-31-4 Strong and Quick Effect USP Standard

Basic Information
Place of Origin: CHINA
Brand Name: TINGYI
Certification: GMP , ISO 9001:2008
Model Number: 1110813-31-4
Minimum Order Quantity: 10g
Price: Contact Me
Packaging Details: Disguised Package
Delivery Time: 2 Working Days
Payment Terms: Bank Transfer - Bitcoin - Western Union - MoneyGram
Supply Ability: 100 KG/Month
Product Name: Dacomitinib CAS: 1110813-31-4
Appearance: White Powder Synonym: PF299
Shipping Method: EMS, HKEMS, FEDEX, DHL, UPS, Aramex, ETC Color: White
High Light:

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Basic Information

Product Name Dacomitinib
CAS No. 1110813-31-4
Molecular Weight 469.9390032
Structure Dacomitinib 1110813-31-4 Strong and Quick Effect USP Standard 0
Purity 99% Min
Character White crystalline powder
Grade Pharmaceutical Grade
Standard USP,CP

Dacomitinib 1110813-31-4 Strong and Quick Effect USP Standard 1

 

 

Description


Dacomitinib is a selective and irreversible inhibitor of EGFR. It is a drug candidate for the treatment of non-small cell lung carcinoma. It is current under the Phase III clinical trials. It also shows potential for the treatment of HER-2 amplified breast cancer cells lines that are resistant to trastuzumab and lapatinib.

 

 

 

Biological activity


Dacomitibib (Dacomitinib, PF299804) is an effective and irreversible pan-ErbB inhibitor that is most effective in EGFR, with an IC50 of 6 nM. It is also highly effective in NSCLCs that carries EGFR or ERBB2 mutants (against Gefitinib) and EGFR T790M mutant. 

 

Dacomitinib is taken orally once-daily. It is an irreversible inhibitor of HER-1 (EGFR), HER-2 and HER-4 tyrosine kinases. Dacomitinib targets multiple receptors of the HER pathway, whereas currently marketed HER-1 (EGFR) inhibitors for non-small cell lung cancer (NSCLC) target only one receptor in this pathway,developed by Pfizer.


Clinical Study Dacomitinib has advanced to several Phase III clinical trials. The results of the first trials were disappointing, with a failure to meet the study goals, Additional Phase III trials are ongoing.

 

Clinical evaluation of dacomitinib is ongoing in a number of clinical trials in patients with advanced NSCLC across lines of therapies and a range of histologies and molecular subtypes, such as EGFR and KRAS status.


Additionally, there is an ongoing clinical trial evaluating dacomitinib in recurrent and/or metastatic (RM) squamous cell carcinoma of the head and neck (SCCHN).

 

 

Uses


PF299804 is a potent, irreversible pan-ErbB inhibitor against ErbB1, ErbB2 and ErbB4 with IC50 of 6 nM, 45.7 nM and 73.7 nM, respectively.

 

 

 

Our Competitive Advantages


1. Rich experience
Our company is a professional production leading factory in China in pharmaceutical area of many years


2. Superior quality, purity and favourable
Our company is a professional leading manufacturer in China in pharmaceutical area.Good quality is one of our secret success.

 

3. Safe and fast delivery
We have GOLDEN FORWARDER and UK Warehouse so we can delivery quickly and safely.

 

4. Package

Professional packing with professional materials.

 

5. Competitive Prices

Low price with high qulity.

 

 

 

FAQ


Q1: Have your Product Quality been Approved by Third Party Lab ?
A: Yes, All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France etc. So you will be assured with Good Quality if you choose us.


Q2. Are you a manufacturer?
A: Yes, we have our own factory and lab.

 

Q3: Is there any discount?
A: Yes, as for old customers and larger quantity, we always support with great discounts and surprise.

 

Q4:Do you accept VISA business credit card ?
A:Sorry we don't accept VISA credit card, we'd like to accept Western Union, MoneyGram, Bank Transfer, Bitcoin, Litecoin.

 

Q5: How do you treat quality complaint?
A: First of all, our QC department will do strict examination of our export products in order to reduce the quality problem to near zero. If there is a real quality problem caused by us, we will send you free goods for replacement or refund your loss.


Q6: How to proceed order?

1st: Please let me know what you need-Which product/Cas No. quantity, and the destination country.
2nd: You send us the purchase order once we come to an agreement on all details.
3rd: Parcel would be delivered upon full payment received.
4th: Express Tracking No.will be provided about the parcels.
5th: You will get the parcels within 7days.
6th: After-sales service would be provided after you receive parcels.

 

Dacomitinib 1110813-31-4 Strong and Quick Effect USP Standard 2

 

General Comments


We have professional team for package and shipment.Fast and secure shipment could be arranged for customs pass guaranteed.

 

Our company has independent import and export authority,also has the certificate of importing and exporting pharmaceutical materials. At the same time we are developed manufactures with mass stock.

Dacomitinib 1110813-31-4 Strong and Quick Effect USP Standard 3

 

 

Contact Details
Sales Manager

WhatsApp : +8613657291547