Dextromethorphan Hydrobromide 125-69-9 Central nervous antitussive Quick Effect

Basic Information
Place of Origin: CHINA
Brand Name: TINGYI
Certification: GMP , ISO 9001:2008
Model Number: 125-69-9
Minimum Order Quantity: 10g
Price: Contact Me
Packaging Details: Disguised Package
Delivery Time: 2 Working Days
Payment Terms: Bank Transfer - Bitcoin - Western Union - MoneyGram
Supply Ability: 100 KG/Month
Product Name: Dextromethorphan Hydrobromide CAS: 125-69-9
Appearance: White Powder Usage: Central Nervous Antitussive
Shipping Method: EMS, HKEMS, FEDEX, DHL, UPS, Aramex, ETC Color: White
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Quick Detail
Product name Dextromethorphan hydrobromide 
CAS 125-69-9
MF C18H26BrNO
MW 352.31
Molecular structure Dextromethorphan Hydrobromide Monohydrate Pharmaceutical Intermediates Antitussive Drug
Assay 99%
Appearance White powder
Usage An antitussive drug

 

 

 

COA
Items of analysis Specification Results
Apperance Practically white crystal or crystalline powder White crystalline powder
FT-IR The sample spectrum correspond to that of the reference standard Conforms
 

UV

 

Not more than 3.0% difference of RS(on anhydrous basis)

 

2.7%

 

Bromide Test

 

Yellow white precipitate forme

 

Conforms

 

Specific rotation A

 

1.8w/v in water:Not more than 1.0%difference of RS

 

0.4%

 

Specific rotation B

 

2.0%w/v in 0.1M HCL: +28℃to +30℃ at 589nm and 20℃(on anhydrous basis)

 

+28.4℃

 

Clarity of solution

 

5.0%w/v in alcohol:Clear and colorless

 

Conforms

 

PH

 

PH

 

5.2-6.5(1 in 100 water solution)

 

5.7

 

Acidity or Alkalinity

 

Not more than 0.4ml of 0.01M HCLconsumed

 

0.30ml

 

Water(by KF Titration)

 

4.0%—5.5%

 

4.9%

 

impurities A,B,C,D

 

For each of impurities A,B,C,D not more than 0.5%

 

Impurities A,B,C,D; Not detected.

 

impurities A,B,C,D

 

Among impurities A,B,C,D not more than one greater than 0.25%

 

0

 

For each of unspecified impurities

 

not more than0.10%

 

﹤0.05%

 

Total impurities

 

not more than 1.0%

 

﹤0.05%

 

Residue on Ignition

 

Not more than 0.1%

 

0.08%

 

N-Dimethylaniline

 

Not more than 0.001%

 

Conforms

 

Phenolic compounds

 

No blue-green color develops

 

Conforms

 

Assay A (by HPLC)

 

98.0%~102.0%(on anhydrous basis)

 

99.9%

 

Assay B(by titration)

 

99.0%~101.0%(on anhydrous basis)

 

99.2%

 

Methanol

 

≤3000ppm

 

N.D

 

Toluene

 

≤890ppm

 

5.8ppm

 

Acetone

 

≤5000ppm

 

Conforms

 

Storage

 

Preserve in tight containers;protected from light

 

Conforms

Conclusion Qualified

 


 

Abstract


Dextromethorphan Hydrobromide is the hydrobromide salt form of dextromethorphan, a synthetic, addictive property. This agent crosses the blood-brain-barrier and activates sigma opioid receptors on the cough center in the central nervous system, thereby suppressing the cough reflex.
 

Dextromethorphan Hydrobromide (DXM or DM) is an antitussive (cough suppressant) drug of the morphinan class with sedative and dissociative properties. It is one of the active ingredients in many over-the-counter cold and cough medicines, including generic labels and store brands, Benylin DM, Mucinex DM, Robitussin, NyQuil, Dimetapp, Vicks, Coricidin, Delsym, TheraFlu, and others. Dextromethorphan has also found numerous other uses in medicine, ranging from pain relief (as either the primary analgesic, or an opioid potentiater) over psychological applications to the treatment of addiction. It is sold in syrup, tablet, spray, and lozenge forms. In its pure form, dextromethorphan occurs as a white powder.

 

 

Description


DXM is also used recreationally. When exceeding label-specified maximum dosages, dextromethorphan acts as a dissociative hallucinogen. Its mechanism of action is via multiple effects, including actions as a nonselective serotonin reuptake inhibitor and a sigma-1 receptor agonist. The major metabolite of DXM, dextrorphan, also acts as an NMDA receptor antagonist. In high doses this produces effects similar to, yet distinct from, the dissociative states created by other dissociative anaesthetic such as ketamine and phencyclidine. As well, the metabolite 3-methoxymorphinan of dextrorphan (thus a second-level metabolite of DXM) produces local anesthetic effects in rats with potency above dextrorphan, but below that of DXM. 

 

 

Usage
The primary use of dextromethorphan is as a cough suppressant, for the temporary relief of cough caused by minor throat and bronchial irritation (such as commonly accompanies the flu and common cold), as well as those resulting from inhaled particle irritants. However, controlled studies have found the symptomatic effectiveness of dextromethorphan similar to placebo.
 
 
 
 
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Dextromethorphan Hydrobromide 125-69-9 Central nervous antitussive Quick Effect 1

 

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