| Place of Origin: | CHINA |
|---|---|
| Brand Name: | TINGYI |
| Certification: | GMP , ISO 9001:2008 |
| Model Number: | 125-69-9 |
| Minimum Order Quantity: | 10g |
| Price: | Contact Me |
| Packaging Details: | Disguised Package |
| Delivery Time: | 2 Working Days |
| Payment Terms: | Bank Transfer - Bitcoin - Western Union - MoneyGram |
| Supply Ability: | 100 KG/Month |
| Product Name: | Dextromethorphan Hydrobromide | CAS: | 125-69-9 |
|---|---|---|---|
| Appearance: | White Powder | Usage: | Central Nervous Antitussive |
| Shipping Method: | EMS, HKEMS, FEDEX, DHL, UPS, Aramex, ETC | Color: | White |
| High Light: | pharmaceutical anabolic steroids,pharmaceutical fine chemicals |
||
| Product name | Dextromethorphan hydrobromide |
| CAS | 125-69-9 |
| MF | C18H26BrNO |
| MW | 352.31 |
| Molecular structure |  |
| Assay | 99% |
| Appearance | White powder |
| Usage | An antitussive drug |
| Items of analysis | Specification | Results | |
| Apperance | Practically white crystal or crystalline powder | White crystalline powder | |
| FT-IR | The sample spectrum correspond to that of the reference standard | Conforms | |
|
UV |
Not more than 3.0% difference of RS(on anhydrous basis) |
2.7% |
|
|
Bromide Test |
Yellow white precipitate forme |
Conforms |
|
|
Specific rotation A |
1.8w/v in water:Not more than 1.0%difference of RS |
0.4% |
|
|
Specific rotation B |
2.0%w/v in 0.1M HCL: +28℃to +30℃ at 589nm and 20℃(on anhydrous basis) |
+28.4℃ |
|
|
Clarity of solution |
5.0%w/v in alcohol:Clear and colorless |
Conforms |
|
|
PH PH |
5.2-6.5(1 in 100 water solution) |
5.7 |
|
|
Acidity or Alkalinity |
Not more than 0.4ml of 0.01M HCLconsumed |
0.30ml |
|
|
Water(by KF Titration) |
4.0%—5.5% |
4.9% |
|
|
impurities A,B,C,D |
For each of impurities A,B,C,D not more than 0.5% |
Impurities A,B,C,D; Not detected. |
|
|
impurities A,B,C,D |
Among impurities A,B,C,D not more than one greater than 0.25% |
0 |
|
|
For each of unspecified impurities |
not more than0.10% |
﹤0.05% |
|
|
Total impurities |
not more than 1.0% |
﹤0.05% |
|
|
Residue on Ignition |
Not more than 0.1% |
0.08% |
|
|
N-Dimethylaniline |
Not more than 0.001% |
Conforms |
|
|
Phenolic compounds |
No blue-green color develops |
Conforms |
|
|
Assay A (by HPLC) |
98.0%~102.0%(on anhydrous basis) |
99.9% |
|
|
Assay B(by titration) |
99.0%~101.0%(on anhydrous basis) |
99.2% |
|
|
Methanol |
≤3000ppm |
N.D |
|
|
Toluene |
≤890ppm |
5.8ppm |
|
|
Acetone |
≤5000ppm |
Conforms |
|
|
Storage |
Preserve in tight containers；protected from light |
Conforms |
|
| Conclusion | Qualified | ||
Abstract
Dextromethorphan Hydrobromide is the hydrobromide salt form of dextromethorphan, a synthetic, addictive property. This agent crosses the blood-brain-barrier and activates sigma opioid receptors on the cough center in the central nervous system, thereby suppressing the cough reflex.
Dextromethorphan Hydrobromide (DXM or DM) is an antitussive (cough suppressant) drug of the morphinan class with sedative and dissociative properties. It is one of the active ingredients in many over-the-counter cold and cough medicines, including generic labels and store brands, Benylin DM, Mucinex DM, Robitussin, NyQuil, Dimetapp, Vicks, Coricidin, Delsym, TheraFlu, and others. Dextromethorphan has also found numerous other uses in medicine, ranging from pain relief (as either the primary analgesic, or an opioid potentiater) over psychological applications to the treatment of addiction. It is sold in syrup, tablet, spray, and lozenge forms. In its pure form, dextromethorphan occurs as a white powder.
Description
DXM is also used recreationally. When exceeding label-specified maximum dosages, dextromethorphan acts as a dissociative hallucinogen. Its mechanism of action is via multiple effects, including actions as a nonselective serotonin reuptake inhibitor and a sigma-1 receptor agonist. The major metabolite of DXM, dextrorphan, also acts as an NMDA receptor antagonist. In high doses this produces effects similar to, yet distinct from, the dissociative states created by other dissociative anaesthetic such as ketamine and phencyclidine. As well, the metabolite 3-methoxymorphinan of dextrorphan (thus a second-level metabolite of DXM) produces local anesthetic effects in rats with potency above dextrorphan, but below that of DXM.
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