Weight Loss Piceatannol 10083-24-6 Raw Powder Strong Effect 99% Purity

Basic Information

Product Name	Piceatannol
CAS	10083-24-6
Purity	99%
Molecular Formula	C14H12O4
Molecular Weight	244.24
EINECS	10083-24-6
Molecular Structure
Payment Method	Western Union, Bank Transfer, MoneyGram, Bitcoin, Litecoin

Description

Piceatannol is a chemical compound with similar structure to resveratrol, being widely existed in vegetables such as grapes, blueberries and passion fruit. It is capable of inhibiting the growth of immature adipocytes, so as to achieve the purpose of weight loss. In addition, it also helps prevent cancer, heart disease and neurological diseases.

In early April 2012, researchers in Purdue University has published a new study in journal, finding that piceatannol can delay the production of new fat cells, and inhibit the growth of immature fat cells into mature cells, which can help control the obesity. The researchers also claim that while this study shows that red wine helps to lose weight, further research is needed to improve the stability and solubility of the white fat to maximize its effect.

Laboratory preparation: 3, 4-dimethoxybenzyl alcohol is used as the starting material; to obtain the target product; the raw material needs to undergo bromination, Arbuzov rearrangement reaction, Wittig-Horner reaction and demethylation reaction.

Biological Activity

Piceatannol is a selective Syk inhibitor with IC50 of ~10 M. Piceatannol is a plant secondary natural product which inhibits the purified thymocyte p40 kinase (the catalytic fragment of Syk), by competing for the peptide or protein substrate binding site with Ki of 15 M. Piceatannol also inhibits the activity of the p56lck protein-tyrosine kinase in LSTRA cell membranes or intact cells.

Piceatannol preferentially inhibits the activity of Syk in comparison to Lyn in in vitro kinase assays. Selective inhibition of Syk by Piceatannol blocks receptor-mediated down-stream cellular responses (inositol 1,4,5-trisphosphate production, secretion, ruffling, and spreading). Piceatannol is a potent inducer of apoptosis in the lymphoma cell line BJAB by causing a concentration-dependent activation of caspase-3 and mitochondrial permeability transition.

Piceatannol but not resveratrol is a very efficient inducer of apoptosis in ex vivo assay with leukemic lymphoblasts of 21 patients suffering from childhood lymphoblastic leukemia (ALL). Piceatannol inhibits TNF-induced NF-B activation and NF-B-mediated gene expression through suppression of IB kinase and p65 phosphorylation.

Piceatannol inhibits the growth of colorectal cancer cell lines and arrests Caco-2 cells in the S phase of the cell cycle. Sequential treatment with Piceatannol and Ara-C yields synergistic growth inhibitory effects against HL-60 cells because of remarkably increased Ara-CTP formation after Piceatannol preincubation.

Exposure of different-stage PC-3 prostate cancer (CaP) cells to Piceatannol also results in cell-type-specific downregulation of mTOR and its upstream and downstream effector proteins, AKT and eIF-4E-BP1.

COA

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