Treat Eczema and Dermatitis Triamcinolone Acetonide 21-acetate 3870-07-3

Basic Information

Product Name	Triamcinolone Acetonide 21-acetate
CAS	3870-07-3
Purity	99%
Molecular Formula	C26H33FO7
Molecular Weight	476.5344232
Molecular Structure
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Description

Triamcinolone acetonide acetate ,as a glucocorticoid drug, is white or almost white crystalline powder, which is odorless and bitter taste. It is slightly soluble in water, ethanol and acetone and soluble in chloroform. It is currently a long-acting glucocorticoid drug widely used in our dermatology clinical application, also known as Block technique, triamcinolone acetonide, Connor music cream and Conor-A. It belongs to adrenocortical hormones drugs and s from the triamcinolone. The effects of glucocorticoid triamcinolone acetonide acetate, similar to the role of triamcinolone, includes anti-inflammatory, anti-allergic, anti-itching and contracting capillaries. The role of its water and sodium retention is weak, while the anti-Inflammatory and anti-allergic effects are stronger and more durable than hydrocortisone (10 to 30 times) and prednisone. Its application in aerosol inhalation treatment of bronchial asthma is strong and lasting. The local curative effect is better than the triamcinolone. Oral is easy to absorb.

Oral administration is 5mg and the bioavailability is about 23%. Its plasma concentration reaches the peak value of 105mg / ml after 1 hour, with a half-life of 2 hours. The intramuscular injection has a slow absorption process, and its effects begin within a few hours, reach to the maximum after 1 or 2 days and last about 2 or 3 weeks; the intradermal and intra-articular injection of this drug has slow-absorption and lasting-effects and the general effects of one injection can be maintained for 1 to 2 weeks or more.

Triamcinolone Acetonide 21-Acetate Application

Triamcinolone acetonide is a synthetic corticosteroid used to treat various skin conditions, to relieve the discomfort of mouth sores, and in nasal spray form, to treat allergic rhinitis. It is a more potent derivative of triamcinolone, and is about eight times as potent as prednisone.

It is also known under the brand names Kenalog (topical) and Volon A as an injection, to treat allergies, arthritis, eye diseases, intestinal problems, and skin diseases. In 2014, the FDA made triamcinolone acetonide an over-the-counter drug in the USA in nasal spray form under the brand name Nasacort.

Triamcinolone acetonide as an intra-articular injectable has been used to treat a variety of musculoskeletal conditions. When applied as a topical ointment, it is used for blistering from poison ivy, oak, and sumac, applied to the skin, avoiding eyes, mouth, and genital area. It provides relatively immediate relief and is used before using oral prednisone. Oral and dental paste preparations are used for treating aphthous ulcers.

As an intravitreal injection, triamcinolone acetonide has been used to treat various eye diseases and has been found useful in reducing macular edema. Drug trials have found it to be as efficient as anti-VEGF drugs in eyes with artificial lenses over a two-year period.

Uncommonly, intramuscular injection of triamcinolone acetonide may be indicated for the control of severe or incapacitating allergic states for which conventional treatments have failed, such as asthma, atopic dermatitis, contact dermatitis, perennial or seasonal allergic rhinitis, serum sickness, and transfusion and drug hypersensitivity reactions.

Triamcinolone acetonide is also used in veterinary medicine as an ingredient in topical ointments and in topical sprays for control of pruritus in dogs. A series of injections with triamcinolone acetonide or another corticosteroid may reduce keloid size and irritation. It is also used as a preinductor and/or inductor of birth in cows.

Many drugs have been demonstrated to increase triamcinolone acetonide concentration in the blood to well above the intended level. Patients should inform doctors about any other drugs they are taking.Triamcinolone acetonide should not be used by those with tuberculosis or untreated fungal, bacterial, systemic viral or herpes simplex infections without consulting a doctor first.

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