Place of Origin: | CHINA |
---|---|
Brand Name: | TINGYI |
Certification: | GMP , ISO 9001:2008 |
Model Number: | CAS: 148553-50-8 |
Minimum Order Quantity: | 10g |
Price: | Contact Us |
Packaging Details: | Stealth And Discreet Packaging |
Delivery Time: | Within 7 Working Days |
Payment Terms: | Bank Transfer - Bitcoin - Western Union - MoneyGram |
Supply Ability: | 2000 KG/Month |
Product Name: | Pregabalin | Synonyms: | Lyrica |
---|---|---|---|
MF: | C8H17NO2 | MW: | 159.23 |
EINECS: | 200-659-6 | Melting Point: | 194-196°C |
Appearance: | Off-White Solid | ||
High Light: | pharmaceutical active ingredients,pharmaceutical fine chemicals |
99.8% High Quality Pregabalin / Lyrica Powder With Safe Delivery & Favorable Price
Description:
Pregabalin is described chemically as (S)-3-(aminomethyl)-5-methylhexanoic acid. The
molecular formula is C8H17NO2 and the molecular weight is 159.23. Pregabalin is a white to off-
white, crystalline solid with a pKa1 of 4.2 and a pKa2 of 10.6. It is freely soluble in water and both
basic and acidic aqueous solutions. The log of the partition coefficient (n-octanol/0.05M
phosphate buffer) at pH 7.4 is 1.35.
LYRICA (pregabalin) Capsules are administered orally and are supplied as imprinted hard-shell
capsules containing 25, 50, 75, 100, 150, 200, 225, and 300 mg of pregabalin, along with
lactose monohydrate, cornstarch, and talc as inactive ingredients. The capsule shells contain
gelatin and titanium dioxide. In addition, the orange capsule shells contain red iron oxide and the
white capsule shells contain sodium lauryl sulfate and colloidal silicon dioxide. Colloidal silicon
dioxide is a manufacturing aid that may or may not be present in the capsule shells. The
imprinting ink contains shellac, black iron oxide, propylene glycol, and potassium hydroxide.
LYRICA (pregabalin) oral solution, 20 mg/mL, is administered orally and is supplied as a clear,
colorless solution contained in a 16 fluid ounce white HDPE bottle with a polyethylene-lined
closure. The oral solution contains 20 mg/mL of pregabalin, along with methylparaben,
propylparaben, monobasic sodium phosphate anhydrous, dibasic sodium phosphate anhydrous,
sucralose, artificial strawberry #11545 and purified water as inactive ingredients.
Application:
Pregabalin belongs to a group of medicines known as anti-epileptic medicines, although it is
prescribed for the treatment of several different conditions. You may have been prescribed it for
the treatment of partial seizures, which is a type of epilepsy. A seizure is a short episode of
symptoms which is caused by a burst of abnormal electrical activity in the brain. With a partial
seizure, the burst of electrical activity stays in one part of the brain. Therefore, you tend to have
localised or 'focal' symptoms. Pregabalin is also prescribed to treat certain types of long-lasting
pain caused by damage to nerves. This type of pain, called neuropathic pain, can be caused by a
number of different conditions, including diabetes (where it is called diabetic neuropathy) and
shingles(where it is called postherpetic neuralgia).
Medical uses:
1. Seizures
Pregabalin is useful when added to other treatments, when those other treatments are not
controlling partial epilepsy. Its use alone is less effective than some other seizure medications.
It is unclear how it compares to gabapentin for this use.
2. Neuropathic pain
The European Federation of Neurological Societies recommends pregabalin as a first line agent
for the treatment of pain associated with diabetic neuropathy, post-herpetic neuralgia, and central
neuropathic pain. A minority obtain substantial benefit, and a larger number obtain moderate
benefit. Other first line agents, including gabapentin and tricyclic antidepressants, are given equal
weight as first line agents, and unlike pregabalin, are available as less expensive generics.
Pregabalin is not recommended for certain other types of neuropathic pain such as pain that of
trigeminal neuralgia or HIV infection and its use in cancer-associated neuropathic pain is
controversial. There is no evidence for its use in the prevention of migraines and gabapentin has
been found not to be useful. It has been examined for the prevention of post-surgical chronic pain,
but its utility for this purpose is controversial.
3. Anxiety disorders
Lab Test Result:
Test Items |
Specification |
Results |
Appearance |
A white to off white powder |
White powder |
Identification |
A. Meets the requirement |
Complies |
B. IR: similar to Reference Substance |
Complies |
|
Loss on drying |
≤0.5% |
0.21% |
Specific Rotation |
+10.0°~+13.0° |
+10.8° |
Related Substances |
Any single impurity ≤0.1% Total impurity ≤0.8% |
0.05% 0.10% |
Purity By HPLC R-isomer |
≤0.15% |
0.10 |
Residue on ignition |
≤0.1% |
0.05% |
Residual solvents |
Isopropyl alcohol ≤5000ppm Ethyl Acetate ≤5000ppm |
150ppm 250ppm |
Heavy metals |
≤10ppm |
Complies |
Chlorides |
≤0.05% |
Complies |
Assay |
98%~102.0% |
99.8% |
Conclusion |
It conforms with EP standard |
|
||
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|