Place of Origin: | CHINA |
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Brand Name: | TINGYI |
Certification: | GMP , ISO 9001:2008 |
Model Number: | CAS: 103-90-2 |
Minimum Order Quantity: | 100g |
Price: | Contact Us |
Packaging Details: | Stealth And Discreet Packaging |
Delivery Time: | Within 7 Working Days |
Payment Terms: | Bank Transfer - Bitcoin - Western Union - MoneyGram |
Supply Ability: | 3000 KG/Month |
Product Name: | 4-Acetamidophenol | Other Name: | Paracetamol |
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MF: | C8H9NO2 | MW: | 151.16 |
EINECS: | 203-157-5 | MP: | 168-172 °C |
FP: | 11 °C | Density: | 1.293 G/cm3 |
Water Solubility: | 14 G/L (20°C) | Appearance: | White Crystalline Solid |
High Light: | pharmaceutical anabolic steroids,pharmaceutical fine chemicals |
Strong Effect Analgesic & Antipyretic 4-Acetamidophenol (Paracetamol) Powder
Description:
This product is acetanilide antipyretic analgesics. By inhibiting ring oxidase and
selectivity in the hypothalamus of the temperature regulating center, the synthesis of
prostaglandins in peripheral vascular expansion, sweating and antipyretic effect, strength of
its antipyretic effect similar to aspirin.
Paracetamol is a widely used over-the-counter analgesic (pain reliever) and antipyretic
(fever reducer). Acetaminophen is the name adopted for this pharmacologic agent in the U. S.
(USAN) and Japan; Paracetamol is approved in a variety of international venues.
Paracetamol is classified as a mild analgesic. It is commonly used for the relief of
headaches and other minor aches and pains and is a major ingredient in numerous cold and flu
remedies. In combination with opioid analgesics, paracetamol can also be used in the
management of more severe pain such as post-surgical pain and providing palliative care in
advanced cancer patients. Though paracetamol is used to treat inflammatory pain, it is not
generally classified as an NSAID because it exhibits only weak anti-inflammatory activity.
Application:
Paracetamol is approved for reducing fever in people of all ages.
Paracetamol is used for the relief of pains associated with many parts of the body. It has
analgesic properties comparable to those of aspirin, while its antiinflammatory effects are
weaker. It is better tolerated than aspirin in patients in whom excessive gastric acid
secretion or prolongation of bleeding time may be a concern.
Paracetamol powder nutritional supplemen Mainly used for amino acid infusion,due to special
wettability, also used in cold cream,osmetics. Serine constitute the human body of several
kinds of essential amino acid of protein a, for the construction of protein has a very
important role.
Research Result:
Since their synthesis in the late 1800s paracetamol (acetaminophen) and phenacetin have
followed divergent pathways with regard to their popularity as mild analgesic/antipyretic drugs.
Initially, paracetamol was discarded in favour of phenacetin because the latter drug was
supposedly less toxic. Today the opposite is true, and paracetamol, along with aspirin, has
become one of the two most popular 'over-the-counter' non-narcotic analgesic agents. This
marked increase in the wide approval attained by paracetamol has been accompanied by the
virtual commercial demise of phenacetin because of its role, albeit somewhat circumstantial, in
causing analgesic nephropathy. Both paracetamol and phenacetin are effective mild analgesics,
suitable for treating mild to moderate pain, and their actions are broadly comparable with those
of aspirin and related salicylates, although they do not appear to possess significant anti-
inflammatory activity. Since a major portion of a dose of phenacetin is rapidly metabolised to
paracetamol, it seems possible that phenacetin owes some of its therapeutic activity to its main
metabolite, paracetamol, whereas its most troublesome side effect (methaemoglobinaemia) is
due to another metabolite, p-phenetidine. The mechanism of action of paracetamol is poorly
defined, although it has been speculated that it may selectively inhibit prostaglandin production in
the central nervous system, which would account for its analgesic/antipyretic properties. The lack
of any significant influence on peripheral cyclooxygenase would explain the absence of anti-
inflammatory activity. At therapeutic doses paracetamol is well tolerated and produces fewer side
effects than aspirin. The most frequently reported adverse effect associated with paracetamol is
hepatotoxicity, which occurs after acute overdosage (usually doses greater than 10 to 15g are
needed) and, very rarely, during long term treatment with doses at the higher levels of the
therapeutic range. Paracetamol damages the liver through the formation of a highly reactive
metabolite which is normally inactivated by conjugation with glutathione. Overdoses of
paracetamol exhaust glutathione stores, thus allowing the accumulation of this toxic metabolite
which covalently binds with vital cell elements and can result in liver necrosis. Glutathione
precursors (notably intravenous N-acetylcysteine) have proved remarkably successful in treating
paracetamol overdose, as long as treatment is initiated within 10 hours.
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