Strong Effect Analgesic & Antipyretic 4-Acetamidophenol ( Paracetamol ) Powder

Basic Information
Place of Origin: CHINA
Brand Name: TINGYI
Certification: GMP , ISO 9001:2008
Model Number: CAS: 103-90-2
Minimum Order Quantity: 100g
Price: Contact Us
Packaging Details: Stealth And Discreet Packaging
Delivery Time: Within 7 Working Days
Payment Terms: Bank Transfer - Bitcoin - Western Union - MoneyGram
Supply Ability: 3000 KG/Month
Product Name: 4-Acetamidophenol Other Name: Paracetamol
MF: C8H9NO2 MW: 151.16
EINECS: 203-157-5 MP: 168-172 °C
FP: 11 °C Density: 1.293 G/cm3
Water Solubility: 14 G/L (20°C) Appearance: White Crystalline Solid
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Strong Effect Analgesic & Antipyretic 4-Acetamidophenol (Paracetamol) Powder



This product is acetanilide antipyretic analgesics. By inhibiting ring oxidase and


selectivity in the hypothalamus of the temperature regulating center, the synthesis of


prostaglandins in peripheral vascular expansion, sweating and antipyretic effect, strength of


its antipyretic effect similar to aspirin.


Paracetamol is a widely used over-the-counter analgesic (pain reliever) and antipyretic


(fever reducer). Acetaminophen is the name adopted for this pharmacologic agent in the U. S.


(USAN) and Japan; Paracetamol is approved in a variety of international venues.

Paracetamol is classified as a mild analgesic. It is commonly used for the relief of


headaches and other minor aches and pains and is a major ingredient in numerous cold and flu


remedies. In combination with opioid analgesics, paracetamol can also be used in the


management of more severe pain such as post-surgical pain and providing palliative care in


advanced cancer patients. Though paracetamol is used to treat inflammatory pain, it is not


generally classified as an NSAID because it exhibits only weak anti-inflammatory activity.



Paracetamol is approved for reducing fever in people of all ages.

Paracetamol is used for the relief of pains associated with many parts of the body. It has


analgesic properties comparable to those of aspirin, while its antiinflammatory effects are


weaker. It is better tolerated than aspirin in patients in whom excessive gastric acid


secretion or prolongation of bleeding time may be a concern.

Paracetamol powder nutritional supplemen Mainly used for amino acid infusion,due to special


wettability, also used in cold cream,osmetics. Serine constitute the human body of several


kinds of essential amino acid of protein a, for the construction of protein has a very


important role.



Research Result:


Since their synthesis in the late 1800s paracetamol (acetaminophen) and phenacetin have


followed divergent pathways with regard to their popularity as mild analgesic/antipyretic drugs.


Initially, paracetamol was discarded in favour of phenacetin because the latter drug was


supposedly less toxic. Today the opposite is true, and paracetamol, along with aspirin, has


become one of the two most popular 'over-the-counter' non-narcotic analgesic agents. This


marked increase in the wide approval attained by paracetamol has been accompanied by the


virtual commercial demise of phenacetin because of its role, albeit somewhat circumstantial, in


causing analgesic nephropathy. Both paracetamol and phenacetin are effective mild analgesics,


suitable for treating mild to moderate pain, and their actions are broadly comparable with those


of aspirin and related salicylates, although they do not appear to possess significant anti-


inflammatory activity. Since a major portion of a dose of phenacetin is rapidly metabolised to


paracetamol, it seems possible that phenacetin owes some of its therapeutic activity to its main


metabolite, paracetamol, whereas its most troublesome side effect (methaemoglobinaemia) is


due to another metabolite, p-phenetidine. The mechanism of action of paracetamol is poorly


defined, although it has been speculated that it may selectively inhibit prostaglandin production in


the central nervous system, which would account for its analgesic/antipyretic properties. The lack


of any significant influence on peripheral cyclooxygenase would explain the absence of anti-


inflammatory activity. At therapeutic doses paracetamol is well tolerated and produces fewer side


effects than aspirin. The most frequently reported adverse effect associated with paracetamol is


hepatotoxicity, which occurs after acute overdosage (usually doses greater than 10 to 15g are


needed) and, very rarely, during long term treatment with doses at the higher levels of the


therapeutic range. Paracetamol damages the liver through the formation of a highly reactive


metabolite which is normally inactivated by conjugation with glutathione. Overdoses of


paracetamol exhaust glutathione stores, thus allowing the accumulation of this toxic metabolite


which covalently binds with vital cell elements and can result in liver necrosis. Glutathione


precursors (notably intravenous N-acetylcysteine) have proved remarkably successful in treating


paracetamol overdose, as long as treatment is initiated within 10 hours.



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