| Place of Origin: | CHINA |
|---|---|
| Brand Name: | TINGYI |
| Certification: | GMP , ISO 9001:2008 |
| Model Number: | CAS: 53179-13-8 |
| Minimum Order Quantity: | 10g |
| Price: | Contact Us |
| Packaging Details: | Stealth And Discreet Packaging |
| Delivery Time: | Within 7 Working Days |
| Payment Terms: | Bank Transfer - Bitcoin - Western Union - MoneyGram |
| Supply Ability: | 600 KG/Month |
| Product Name: | Pirfenidone | Other Name: | Amr-69 |
|---|---|---|---|
| MF: | C12H11NO | MW: | 185.22 |
| MP: | 96-97°C | Solubility DMSO: | ≥10 Mg/mL, Soluble |
| Appearance: | Off-White Solid | ||
| High Light: | pharmaceutical active ingredients,pharmaceutical fine chemicals |
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Anti-Inflammatory Pharmaceutical Raw Powder Pirfenidone Powder
Description:
Pirfenidone is an orally active small molecule drug that may inhibit collagen synthesis, down
regulate production of multiple cytokines and block fibroblast proliferation and stimulation in
response to cytokines. Pirfenidone has demonstrated activity in multiple fibrotic conditions,
including those of the lung, kidney and liver. It is being investigated by InterMune.
Introduction:
In vitro, pirfenidone can inhibit the uterine flesh tumour cells and leiomyoma cells proliferation.
Pirfenidone can inhibit the TGF - beta - 1 inducing fibroblast collagen formation. Inhibition of
PDGF, FGF and TGF - beta - 1 inducing fibroblast proliferation. In hamster model, pirfenidone,
taken by mouth, that can the prevention and treatment of pulmonary fibrosis induced by
bleomycin. Pirfenidone can prevent the sclerosing peritonitis in rats induced by chemical, can
also be keloid grafting for the treatment of nude mice. Pirfenidone 0.01 1 mg/ml can suppress the
matrix and dose dependent manner serum stimulate uterine fibroids and leiomyoma cell DNA
synthesis, the compound has no cytotoxic effect, has no effect on collagen mRNA level also.
Pirfenidone in hamster pulmonary fibrosis model can reduce the disease before the collagen I
mRNA level enhancement, reduce the level of the lung hydroxyproline and malondialadehyde and
lung preserved ammonia acyl hydroxylase activity.
Application:
pirfenidone is an anti-inflammatory drug used to treat idiopathic pulmonary fibrosis.Antifibrotic
agent, effective in models of pulmonary and lung fibrosis. Inhibits collagen production and
fibroblast proliferation. Regulates cytokine levels following oral administration in vivo. Potent
scavenger of free radicals and inhibitor of lipid peroxidation.Pirfenidone inhibits collagen
production and fibroblast proliferation. It has shown antifibrotic and anti-inflammatory properties
in variety of animal models of pulmonary fibrosis, and in clinical trials.
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