| Place of Origin: | CHINA |
|---|---|
| Brand Name: | TINGYI |
| Certification: | GMP , ISO 9001:2008 |
| Model Number: | CAS: 145-13-1 |
| Minimum Order Quantity: | 10g |
| Price: | Contact Us |
| Packaging Details: | Stealth And Discreet Packaging |
| Delivery Time: | Within 7 Working Days |
| Payment Terms: | Bank Transfer - Bitcoin - Western Union - MoneyGram |
| Supply Ability: | 300 KG/Month |
| Product Name: | Pregnenolone | MF: | C21H32O2 |
|---|---|---|---|
| MW: | 316.48 | EINECS: | 205-647-4 |
| MP: | 188-190 °C | Storage Temp: | -20°C Freezer |
| Appearance: | White Crystalline Powder | ||
| High Light: | pharmaceutical active ingredients,pharmaceutical anabolic steroids |
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99.25% High Assay Steroid Intermediate Pregnenolone Raw Powder
Description :
Pregnenolone and its sulfate, like DHEA and its sulfate and progesterone, belong to the group of
neurosteroids that are found in high concentrations in certain areas of the brain, and are
synthesized there. Neurosteroids affect synaptic functioning, are neuroprotective, and enhance
myelinization. Pregnenolone and its sulfate ester are under investigation for their potential to
improve cognitive and memory functioning. Pregnenolone is also being considered as a potential
treatment for schizophrenia.
Interestingly, unlike pregnenolone, pregnenolone sulfate is a negative allosteric modulator of the
GABAA receptor as well as a positive allosteric modulator of the NMDA receptor. In addition, it
has been shown to activate the transient receptor potential M3 (TRPM3) ion channel in
hepatocytes and pancreatic islets causing calcium entry and subsequent insulin release.
Pregnenolone, a molecule produced by the brain, acts as a natural defense mechanism against
effects of cannabis/marijuana in animals. Pregnenolone prevents THC/Tetrahydrocannabinol, the
main active principle in cannabis, from fully activating its brain receptor, the CB1 receptor, that
when overstimulated by THC/Tetrahydrocannabinol causes the intoxicating effects of
cannabis/marijuana.
Pregnenolone undergoes further steroid metabolism in one of three ways.
Pregnenolone can be converted to progesterone. The critical enzyme step is two-fold using a 3-
beta-hydroxysteroid dehydrogenase and a delta 4-5 isomerase. The latter transfers the double
bond from C5 to C4 on the A ring. Progesterone is the entry into the delta-4-pathway, resulting in
production of 17-hydroxy progesterone and andros tenedione, precursor to test osterone and
estrone. Aldosterone and corticosteroids are also derived from progesterone or its derivatives.
Pregnenolone can be converted to 17-hydroxy-pregnenolone by the enzyme 17α-hydroxylase
(CYP17A1). Using this pathway, termed delta-5 pathway, the next step is conversion to
dehydroepiandros terone (DH EA) using a desmolase. DH EA is the precursor of andros
tenedione.
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