Dexamethasone Acetate / Palmitate Raw Material For Medicine Manufacturing

Basic Information
Place of Origin: CHINA
Brand Name: TINGYI
Certification: GMP , ISO 9001:2008
Model Number: CAS: 50-02-2
Minimum Order Quantity: 10g
Price: Contact Us
Packaging Details: Stealth And Discreet Packaging
Delivery Time: Within 7 Working Days
Payment Terms: Bank Transfer - Bitcoin - Western Union - MoneyGram
Supply Ability: 2500 KG/Month
Product Name: Dexamethasone MF: C22H29FO5
MW: 392.46 EINECS: 200-003-9
MP: 262-264 °C Appearance: White Solid
High Light:

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Dexamethasone & Dexamethasone-17-acetate & Dexamethasone Palmitate


Basic Details:


Product Name: Dexamethasone

Synonyms: Acidocont; Deronil; Dexacortal; dexametona; Flumeprednisolon

CAS: 50-02-2

MF: C22H29FO5

MW: 392.46

EINECS: 200-003-9

mp: 262-264 °C(lit.)

alpha: 75 °(c=1, dioxane)

refractive index: 76 ° (C=1, Dioxane)

storage temp: 2-8°C

solubility ethanol: 1 mg/mL

appearance: white solid

Water Solubility: 10 mg/100 mL (25°C)

Stability: Stable. Combustible. Incompatible with strong oxidizing agents, strong bases, acid


anhydrides, acid chlorides. May be light sensitive




It is usually given by the inhaled route for direct effect on bronchial smooth muscle.This is usually


achieved through a metered dose inhaler (MDI), nebulizer or other proprietary delivery devices


(e.G.Rotahaler or Autohaler).In these forms of delivery, the maximal effect of salbutamol can take


place within five to 20 minutes of dosing, though some relief is immediately seen.It can also be


given intravenously.


Used in the treatment of bronchial asthma, asthmatic bronchitis, emphysema, patients







Basic Details:


Product Name: Dexamethasone-17-acetate

Synonyms: Dexamethason Acetate

CAS: 1177-87-3

MF: C24H31FO6

MW: 434.5

EINECS: 214-646-8

mp: 238-240 °C(lit.)

refractive index: 87 °(C=1, Dioxane)

storage temp: 2-8°C

appearance: Off-White Solid




Dexamethasone-17-acetate, a corticosteroid, is similar to a natural hormone produced by your


adrenal glands. It often is used to replace this chemical when your body does not make enough of


it. It relieves inflammation (swelling, heat, redness, and pain) and is used to treat certain forms of


arthritis; skin, blood, kidney, eye, thyroid, and intestinal disorders; severe allergies; and asthma.


Dexamethasone-17-acetate is also used to treat certain types of cancer.


Dexamethasone-17-acetate comes as a tablet and a solution to take by mouth. Your doctor will


prescribe a dosing schedule that is best for you. Follow the directions on your prescription label


carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take


Dexamethasone-17-acetate exactly as directed. Do not take more or less of it or take it more


often than prescribed by your doctor.



Special Note:

Do not stop taking Dexamethasone-17-acetate without talking to your doctor. Stopping the drug


abruptly can cause loss of appetite, upset stomach, vomiting, drowsiness, confusion, headache,


fever, joint and muscle pain, peeling skin, and weight loss. If you take large doses for a long time,


your doctor probably will decrease your dose gradually to allow your body to adjust before


stopping the drug completely. Watch for these side effects if you are gradually decreasing your


dose and after you stop taking the tablets or oral liquid, even if you switch to an inhalation


corticosteroid medication. If these problems occur, call your doctor immediately. You may need to


increase your dose of tablets or liquid temporarily or start taking them again.



                                   Dexamethasone Palmitate



Basic Details:


Product Name: Dexamethasone palmitate

Synonyms: DXP;Limethason;Lipotalon

CAS: 14899-36-6

MF: C38H59FO6

MW: 630.87

mp: 60-65 °C

density: 1.12

storage temp: Hygroscopic, -20°C Freezer, Under Inert Atmosphere

appearance: Colourless Thick Oil




Dexamethasone palmitate (DXP) is a lipophilic prodrug of dexamethasone (DXM), a potent


corticosteroide used to treat a variety of ophthalmic diseases. The aim of the study was to


characterize the sustained release capacity (in rabbit), efficacy (in rat and rabbit), and safety (in


rabbit, cat, and minipig) of intravitreal (IVT) DXP emulsions in preclinical models.




Oil-in-water emulsions of DXP were administered by IVT injections in rats, rabbits, cats, or


minipigs. Efficacy was assessed in rabbits by the inhibition of VEGF-induced vascular leakage


and in rats by inhibition of laser-induced choroidal neovascularization. Concentrations of DXP


and DXM in aqueous humor, vitreous, retina, choroid, and blood were determined to characterize


the ocular and systemic pharmacokinetic (PK) profile. Complete ophthalmic examinations


(indirect ophthalmoscopy, slit-lamp biomacroscopy, electroretinography, tonometry) were


performed to assess the ocular safety of IVT DXP doses up to 2,600 μg in minipig, followed by


histopathologic examinations. A validated feline model of DXM-induced elevated intraocular


pressure (IOP) was used to assess the ocular hypertensive impact (i.e., the safety) of an IVT


injection of DXP emulsion.



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