99.05% High Purity Pharmaceutical Intermediate Misoprostol White Solid

99.05% High Purity Pharmaceutical Intermediate Misoprostol White Solid

Description:
 

Misoprostol is a medication used to start labor, induce abortions, prevent and treat stomach

ulcers, and treat postpartum bleeding due to insufficient contraction of the uterus. For abortions it

is used with mifepristone or methotrexate. It is a synthetic prostaglandin E1 (PGE1).
 

Common side effects include diarrhea and abdominal pain. It is pregnancy category X meaning

that it is known to result in negative fetal outcomes if taken during pregnancy. Uterine rupture may

occur.

Usage:
 

Misoprostol acts upon gastric parietal cells, inhibiting the secretion of gastric acid by G-protein

coupled receptor-mediated inhibition of adenylate cyclase, which leads to decreased intracellular

cyclic AMP levels and decreased proton pump activity at the apical surface of the parietal cell.

Because other classes of drugs, especially H2-receptor antagonists and proton pump inhibitors,

are more effective for the treatment of acute peptic ulcers, misoprostol is only indicated for use by

people who are both taking NSAIDs and are at high risk for NSAID-induced ulcers, including the

elderly and people with ulcer complications. Misoprostol is sometimes coprescribed with

NSAIDs to prevent their common adverse effect of gastric ulceration.
 

Misoprostol has other protective actions, but is only clinically effective at doses high enough to

reduce gastric acid secretion. For instance, at lower doses, misoprostol may stimulate increased

secretion of the protective mucus that lines the gastrointestinal tract and increase mucosal blood

flow, thereby increasing mucosal integrity. However, these effects are not pronounced enough to

warrant prescription of misoprostol at doses lower than those needed to achieve gastric acid

suppression.
 

However, even in the treatment of NSAID-induced ulcers, omeprazole proved to be at least as

effective as misoprostol,but was significantly better tolerated, so misoprostol should not be

considered a first-line treatment. Misoprostol-induced diarrhea and the need for multiple daily

doses are the main issues impairing compliance with therapy.