Effective Prilocaine Local Anesthetic Powder Pharmaceutical Raw Materials For Pain Relief

99% USP Effective Local Anesthetic Raw Material Prilocaine White Crystal

Description:
 

Prilocaine belongs to amide local anesthetic drug with its anesthesia intensity and speed being

similar as lidocaine but with a longer duration period and weaker effect on vasodilation. It has a

lower toxicity than lidocaine. It is clinically for local anesthesia, especially suitable for treating

patients who are not allowed to use adrenaline.

[Pharmacological] its 3% solution has a similar local anesthesia efficacy as the anesthesia drug

of 2% lidocaine together with adrenaline. It has a slow onset time which lasts about 6~7min and

the duration time of about 1.5~2h. It has a strong penetration capability through mucous

membranes. Adrenaline has a slightly prolonged duration of action. PPB is 55% and T1/2 of

about 1.5h. It is subject to liver metabolism with its metabolites nitroso toluidine being able to

oxidize hemoglobin to form methemoglobin. It can be transported to the fetus through the

placenta.

[Adverse reactions] once the usage amount exceeds 600mg, methaemoglobinaemia can occur

with cyanosis, tachycardia, headache, dizziness and weakness occurring.
 

[Note] patients of anemia, congenital or acquired methaemoglobinaemia, respiratory failure or

heart failure and hypoxic patients should be disabled. It is forbidden for applied to obstetric

anesthesia.

[Usage and dosage] infiltration anesthesia: 0.5% to 1% solution with the duration of action of 1 to

1.5 hours.
 

Nerve blocking anesthesia: use 1% to 2% solution with the duration of action being 2-3 hours.
 

Epidural anesthesia: use10 to 30 mL of 1.5%~1% solution with the duration of action of 2.5 to 3.5

hours. Use a maximum dose of 600 mg.

Chemical Properties It is a kind of needle-like crystals with the melting point being 37-38 ℃ and

the boiling point being 159-162 ℃ (0.133kPa), and refractive index (nD20) being 1.5299. Its

hydrochloride ([1786-81-8]) is a white crystalline powder. The Melting point is 167-168 ℃. It is

soluble in water and ethanol, slightly soluble in chloroform. It has sour taste and bitter taste and is

odorless.

Uses It is a kind of local anesthetic drug. The product has better efficacy than procaine and the

local anesthesia intensity and speed being similar as lidocaine but with longer duration time and

less toxicity as well as smaller accumulation effect. It is suitable for epidural anesthesia,

conduction anesthesia and infiltration anesthesia.