Amino Amide Local Anesthetic Powder Propitocaine Hydrochloride / HCL

Local Anesthetic Propitocaine Hydrochloride / Propitocaine HCL Powder

Description:

1. Prilocaine is a local anesthetic of the amino amide type. Prilocaine is often used in dentistry.

Prilocaine is also often combined with lidocaine as a preparation for dermal anesthesia

(lidocaine/pril ocaine or EMLA), for treatment of conditions like paresthesia.

 

2. Local anesthetic is a substance that causes loss of sensation only to the area to which it is

applied without affecting consciousness. Most local anesthetics structures have amino-ester or

an amino-amide group which are linked to hydrophilic (secondary or tertiary amine) and to

hydrophobic group (aromatics) on the other sid.

 

3. The ester can be hydrolysed in plasma by the enzyme pseudocholinesterase into para-

aminobenzoic acid. Amide is stable for longer acting and more systemic distribution. Ester types

include Procaine (Novocain), Chloroprocaine (Nesacaine), Tetracaine (Pontocaine),

Benzocaine, Tetracaine. Amide types include Lidocaine (Xylocaine),
 

4. Mepivacaine(Carbocaine), Prilocaine (Citanest), Bupivacaine (Marcaine), Etidocaine

Application:
 

Prilocaine is a local anesthetic of the amino amide type. In its injectable form (trade name

Citanest), it is often used in dentistry. It is also often combined with lidocaine as a preparation for

dermal anesthesia, for treatment of conditions like paresthesia. As it has low cardiac toxicity, it is

commonly used for intravenous regional anaesthesia (IVRA). In some patients, a metabolite of

prilocaine may cause the unusual side effect of methemoglobinemia, which may be treated
 

with methylene blue. Maximum dosage for dental use: 8.0 mg/kg (2.7 mg/lb), with a maximum

dose of 500 mg. Eutectic Mixture of Local Anesthetics (EMLA) containing 5% lidocaine and

prilocaine in a cream was found to give effective topical analgesia in normal and diseased skin,

making it useful for superficial surgery and various other clinical procedures. To be effective, an

adequate amount must be applied under occlusion and at the right time before the intervention.