USA FDA Approved Sleep Promoting Drug Tasimelteon Raw Powder CAS 609799-22-6

USA FDA Approved Sleep Promoting Drug Tasimelteon Raw Powder

Description:

Tasimelteon is a melatonin receptor agonist. Because of the high density of melatonin receptors

in the circadian pacemaker, the suprachiasmatic nucleus, melatonergic actions can phase-shift

circadian rhythms and promote sleep. Tasimelteon was effective in reducing sleep onset latency

(in phase II and III clinical trials) and in resetting the circadian melatonin rhythm (in phase II trials),

which indicated its potential suitability as treatment for jet lag, shift work and circadian rhythm

sleep disorders. Statistically significant improvements in sleep maintenance have also been

observed with the drug. Tasimelteon has been claimed to be useful in the treatment of

depression, and preclinical evidence in this respect is to be confirmed in a phase II clinical trial,

which was ready to be initiated at the time of publication. It is plausible that the drug may be

effective in the treatment of depressive disorders, at least those that are related to circadian

dysfunction, and that it may attenuate sleep problems in depressed patients of different subtypes.

A general suitability in mitigating other symptoms of major depressive disorder cannot be

deduced from the actions of tasimelteon via the melatonin receptors MT1 and MT2. The drug is

well tolerated, does not induce impairment of next-day functioning or dependence, and seems to

be safe in short-term treatment; however, toxicological data would be required for assessing its

long-term safety.