Antihypertensive / Antianginal / Antiarrhythmic Pharmaceutical Products Propranolol Hydrochloride

                  Important Pharmaceutical Product Propranolol Hydrochloride Powder
 
 
Basic Details:

Product Name: Propranolol hydrochloride
 

CAS: 318-98-9
 

MF: C16H22ClNO2
 

MW: 295.8
 

EINECS: 206-268-7

Usage: Adrenergic blocker. Antihypertensive; antianginal; antiarrhythmic (class II) ; For

the prophylaxis of migraine

Chemical Properties:
 

mp: 163-165 °C(lit.)
 

storage temp: 2-8°C
 

solubility H2O: 50 mg/mL, clear, colorless
 

Water Solubility: SOLUBLE
 

Merck: 14,7840
 

Appearance: Off-White to Light-Yellow Cyrstalline Solid

Safety Information:
 

Hazard Codes: Xn,Xi,T,F
 

Risk Statements: 22-39/23/24/25-23/24/25-11
 

Safety Statements: 22-45-36/37-16-7
 

WGK Germany: 3
 

RTECS: UB7525000
 

F: 10
 

HazardClass: IRRITANT

Description:
 

Propranolol is a medication of the beta blocker type. It is used to treat high blood pressure, a

number of types of irregular heart rate, thyrotoxicosis, capillary hemangiomas, performance

anxiety, and essential tremors. It is used to prevent migraine headaches, and to prevent further

heart problems in those with angina or previous heart attacks. It can be taken by mouth or by

injection into a vein. The formulation that is taken by mouth comes in short acting and long acting

versions. Propranolol appears in the blood after 30 minutes and has a maximum effect between

60 and 90 minutes when taken by mouth .

Common side effects include nausea, abdominal pain, and constipation. It should not be used in

those with an already slow heart rate and most of those with heart failure. Quickly stopping the

medication in those with coronary artery disease may worsen symptoms. It may worsen the

symptoms of asthma. Greater care is recommended in those with liver or kidney problems.

Propranolol may cause harmful effects in the baby if taken during pregnancy. Its use during

breastfeeding is probably safe, but the baby should be monitored for side effects. It is a non-

selective beta blocker which works by blocking β-adrenergic receptors.

Propranolol was discovered in 1964. It is on the World Health Organization's List of Essential

Medicines, the most effective and safe medicines needed in a health system. Propranolol is

available as a generic medication .

Usage:
 

Propranolol is indicated for the management of various conditions including: Hypertension;

Angina pectoris; Tachyarrhythmias; Myocardial infarction; Control of tachycardia/tremor

associated with anxiety, hyperthyroidism or lithium therapy; Essential tremor; Sex Change;

Migraine prophylaxis; Cluster headaches prophylaxis; Tension headache (Off label use); Shaky

hands.